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MetabolomicsLC-HRMS-Driven Computational Toolbox to Assess Extraction Protocols Dedicated to Untargeted Analysis: How to Ease Analyzing Pesticide-Contaminated Soils?
Metabolomics is a powerful approach that allows for high throughput analysis and the acquisition of large biochemical data. Nonetheless, it still faces several challenging requirements, such as the development of optimal extraction and analytical methods able to respond to its high qualitative and q...
2025-01-28 | MTBLS2044 | MetaboLights
MetabolomicsHigh-performance nano-flow liquid chromatography column combined with high- and low-collision energy data-independent acquisition enables targeted and discovery identification of modified ribonucleotides by mass spectrometry (Data-independent acquisition)

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their ...

2023-10-26 | MTBLS2959 | MetaboLights
MetabolomicsPlasma metabolomics data in the Wenzhou Parkinson's disease cohort
To discriminate plasma metabolomic profiles between Parkinson’s disease (PD) and healthy controls (HC) in Wenzhou, China, we performed liquid chromatography–mass spectrometry (LC–MS) analysis in a cohort comprising 140 PD patients and 72 HC participants. Plasma samples were subjected to LC–MS metabo...
2026-08-24 | MTBLS15442 | MetaboLights
MetabolomicsHigh-performance nano-flow liquid chromatography column combined with high- and low-collision energy data-independent acquisition enables targeted and discovery identification of modified ribonucleotides by mass spectrometry (Mixed-mode column chromatography)

Over 170 post-transcriptional RNA modifications have been described and are common in all kingdoms of life. These modifications range from methylation to complex chemical structures, with methylation being the most abundant. RNA modifications play a key role in RNA folding and function and their ...

2023-10-26 | MTBLS2497 | MetaboLights
MetabolomicsUntargeted In Silico Compound Classification - A Novel Metabolomics Method to Assess the Chemodiversity in Bryophytes

In plant ecology, biochemical analyses of bryophytes and vascular plants are often conducted on dried herbarium specimen as species typically grow in distant and inaccessible locations. Here, we present an automated in silico compound classification framework to annotate metabolites using an unta...

2026-01-30 | MTBLS851 | MetaboLights
ProteomicsCharacterization of Androctonus mauretanicus Venom and In Vitro Screening of SARS-CoV-2 Entry Inhibitors Candidates
The project focuses on the characterization and exploration of the bioactive components of Androctonus mauritanicus scorpion venom, with an emphasis on proteomic profiling and peptide identification. The overarching goal is to generate a comprehensive dataset of venom peptides and proteins, which ca...
ORGANISM(S): mixed culture metagenome 
2025-10-08 | PXD069182 | Pride
Proteomics Antiviral peptides Mass spectrometry Sars-cov-2 Scorpion venom Androctonus mauritanicus 
TranscriptomicsThe effects of timing of fine needle aspiration biopsies on gene expression profiles in breast cancers
Paired fine needle aspiration biopsies (FNABs) of breast cancers were taken before (PRE) and after (POST) surgeries from 16 patients and compared the cDNA microarray data to determine the genes that were differentially expressed between the FNABs taken at the two time points. The timing of fine need...
ORGANISM(S): Homo sapiens 
2008-09-09 | E-GEOD-12072 | biostudies-arrayexpress
ProteomicsImproved Profiling of Low Molecular Weight Serum Proteome for Gastric Carcinoma by Data-independent Acquisition
Low molecular weight proteins (LMWPs) in the bloodstream participate in various biological processes and are closely associated with disease status, whereas identification of serous LMWPs remains a great technical challenge due to the wide dynamic range of protein components. In this study, we const...
ORGANISM(S): Homo sapiens (Human) 
2022-07-11 | PXD034184 | Pride
Mass spectrometer Quantitative proteomics Data-independent acquisition (dia) Low molecular weight proteins (lmwps) Gastric carcinoma (gc) 
ProteomicsDIA data analysis with unambiguously determined precursor mass
Proteomics research today no longer simply seeks exhaustive protein identification; now, robust, large-scale quantitative information is sought. For this purpose, data-independent acquisition (DIA) has emerged as a promising strategy largely owing to the developments in advanced mass spectrometers a...
ORGANISM(S): Homo sapiens (Human) 
2019-08-19 | PXD012744 | Pride
Precursor mass Dia 
ProteomicsMultiplex Biomarker Screening Assay for Urinary Extracellular Vesicles Study: A Targeted Label-Free Proteomic Approach
The recent advance in targeted label-free proteomics, SWATH-MS, can provide consistent protein detection and reproducible protein quantitation, which is a considerable advantage for biomarker study of urinary exosome-enriched extracellular vesicles (EVs). We developed a SWATH-MS workflow with a cura...
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD008891 | Pride
Biomarker  exosomes  human urine  microvesicles  post-acquisition data extraction  proteome 
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