prdm9/zcwpw1/zcwpw2 system - OmicsDI

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West China Second University Hospital, Sichuan University (2)

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A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional control in humans and mice

Meiotic recombination ensures proper chromosome segregation and genetic diversity during gametogenesis, and its disruption leads to infertility. It is known that the dual histone methylation writer–reader system, in which PRDM9 deposits H3K4me3 and H3K36me3 marks at nucleosomes to specify recombinat...

ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)

2026-01-07 | PXD068838 | Pride

Meiotic recombination zcwpw1–zcwpw2 complex prdm9/zcwpw1/zcwpw2 system ldha ep300 lactylation

A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional control in humans and mice

Meiotic recombination ensures proper chromosome segregation and genetic diversity during gametogenesis, and its disruption leads to infertility. It is known that the dual histone methylation writer–reader system, in which PRDM9 deposits H3K4me3 and H3K36me3 marks at nucleosomes to specify recombinat...

ORGANISM(S): Homo sapiens (Human)

2026-01-07 | PXD070427 | Pride

Meiotic recombination zcwpw1–zcwpw2 complex prdm9/zcwpw1/zcwpw2 system ldha ep300 lactylation

A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional regulation in humans and mice.

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S-EPMC12828234 | biostudies-literature

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