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ProteomicsSex-specific proteomic profiling identifies pregnancy zone protein as a complement-linked marker of adverse prognosis in esophageal adenocarcinoma
Esophageal adenocarcinoma (EAC) exhibits marked male predominance with male-to-female ratios reaching 8.5:1, yet the molecular basis underlying this sex disparity remains poorly characterized. We analyzed 92 EAC specimens using mass spectrometry–based proteomics, comprising 47 female and 45 male tum...
ORGANISM(S): Homo sapiens (Human) 
2026-06-25 | PXD078617 | Pride
Esophageal adenocarcinoma  sex differences  proteomics  pregnancy zone protein 
TranscriptomicsLeptin and the Placental Response to Maternal Food Restriction during Early Pregnancy
Concentrations of leptin decline during food restriction. This study was designed to test the hypothesis that some of the effects of maternal food restriction on placental development are mediated by the loss of leptin. Mice were randomized to 3 treatment groups on day 1.5 of pregnancy: (1) ad libi...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-38095 | biostudies-arrayexpress
TranscriptomicsPregnancy changes expression in peripheral blood mononuclear cells of healthy donors
Background: pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood. This data series contains the subset of data used to generate a healthy donors signature comp...
ORGANISM(S): Homo sapiens 
2010-01-09 | E-GEOD-17409 | biostudies-arrayexpress
TranscriptomicsPregnancy changes expression in peripheral blood mononuclear cells of Multiple Sclerosis (MS) patients
Background: pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood. This data series contains the subset of data used to generate a MS signature comparing female...
ORGANISM(S): Homo sapiens 
2010-01-10 | E-GEOD-17410 | biostudies-arrayexpress
TranscriptomicsExpression data from junctional zone of placenta in Brown Norway and Holtzman-Sprague Dawley rat strains at gestation day 18.5
Placentation differs in the BN rat strain when compared to HSD and DSS rat strains. Intrauterine trophoblast invasion is shallow and the junctional zone is underdeveloped in the BN rat. These structural differences are striking but their quantification is not conducive to high throughput analyses. I...
ORGANISM(S): Rattus norvegicus 
2011-05-13 | E-GEOD-29247 | biostudies-arrayexpress
UnknownHuman pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer's-associated amyloid beta peptide.
Not available
S-EPMC6442606 | biostudies-literature
UnknownHepatokine Pregnancy Zone Protein Governs the Diet-Induced Thermogenesis Through Activating Brown Adipose Tissue.
Not available
S-EPMC8564441 | biostudies-literature
UnknownPrognostic Significance of Pregnancy Zone Protein and Its Correlation with Immune Infiltrates in Hepatocellular Carcinoma.
Not available
S-EPMC7553665 | biostudies-literature
GenomicsIdentification of Angustifolia 3 (ZmAN3) target genes through GSyellow-based ChIP-seq in Zea mays leaves
Genome-wide target genes of ZmAN3 were identified through ChIP-seq on the growth zone of the maize leaf, encompassing the division, transition and expansion zone. For ChIP-seq, ZmAN3 was fused to the GSyellow TAP tag and expressed from the ubiquitin promoter (pUBIL). The pUBIL:ZmAN3-GSyellow constru...
ORGANISM(S): Zea mays 
2018-08-07 | E-MTAB-6527 | biostudies-arrayexpress
TranscriptomicsTranscription signature of Multiple Sclerosis in peripheral blood mononuclear cells.
Background: pregnancy is associated with reduced activity of multiple sclerosis (MS). However, the biological mechanisms underlying this pregnancy-related decrease in disease activity are poorly understood. This data series contains the subset of data used to generate a MS signature comparing female...
ORGANISM(S): Homo sapiens 
2010-01-10 | E-GEOD-17393 | biostudies-arrayexpress
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