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Over the past 5–7 million years, humans and chimpanzees have diverged in brain size, structural complexity, and cognitive abilities despite high conservation of protein-coding genes. Notably, the endogenization and proliferation of retroviral infections within host genomes has introduced numerous sp...
ORGANISM(S): Homo sapiens (Human) 
2026-09-16 | PXD071764 | Pride
Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which of these changes are biologically relevant and underlie the emergence of the human brain or its unique susceptibility to neural disease has been challenging. Here we a...
ORGANISM(S): Callithrix jacchus Macaca mulatta Homo sapiens Pan troglodytes 
2019-12-20 | GSE130871 | GEO
Genomics
Adaptive Functions of Structural Variants in Human Brain Development
Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients
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