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UnknownMutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo.
Not available
S-EPMC3737180 | biostudies-literature
ProteomicsA conservative point mutation in a dynamic antigen-binding loop of human immunoglobulin λ6 light chain promotes pathologic amyloid formation
Immunoglobulin light chain (LC) amyloidosis (AL) is a life-threatening human disease wherein free monoclonal LCs deposit in vital organs. To determine what makes some LCs amyloidogenic, we explored patient-based amyloidogenic and non-amyloidogenic recombinant LCs from the λ6 subtype prevalent in AL....
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD026528 | Pride
Light chain amyloidosis  protein conformation  hydrogen-deuterium exchange mass spectrometry  propagation of mutational effects  cdr loops 
UnknownRole of Purine-Rich Regions in Mason-Pfizer Monkey Virus (MPMV) Genomic RNA Packaging and Propagation.
Not available
S-EPMC7674771 | biostudies-literature
UnknownMolecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT.
Not available
S-EPMC3545441 | biostudies-literature
UnknownPropagation of conformational instability in FK506-binding protein FKBP12.
Not available
S-EPMC10939819 | biostudies-literature
UnknownNaturally-Occurring Rare Mutations Cause Mild to Catastrophic Effects in the Multifunctional and Cancer-Associated NQO1 Protein.
Not available
S-EPMC7711955 | biostudies-literature
GenomicsCombined Functional and Genomic Single clonal Stem Cell Analysis Pinpointed at Diagnosis Leukemic Clones Responsible for Acute Myeloid Leukemia Relapse
Acute myeloid leukemia (AML) is a hematological malignancy, associated with unfavorable patient outcome primarily due to disease relapse. Since specific early leukemic hematopoietic stem and progenitor cells (HSPCs) are suggested to be responsible for AML propagation, the present study used single c...
ORGANISM(S): Homo sapiens 
2022-11-12 | E-MTAB-12238 | biostudies-arrayexpress
UnknownDefining essential charged residues in fibril formation of a lysosomal derived N-terminal α-synuclein truncation.
Not available
S-EPMC12019160 | biostudies-literature
GenomicsGSDME as a rheostat in cell survival and mutagenesis
Determining the mutational burden of tumor cells that survive apoptotic caspase activation in the presence or absence of Gasdermin E
PRJEB88711 | ENA
UnknownAccelerated rates of large-scale mutations in the presence of copper and nickel.
Not available
S-EPMC6314161 | biostudies-literature
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