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ProteomicsStructure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating membrane drug targets that cannot be fully inhibited using traditional inhibitors. Several ingenious chimeras have been developed...
ORGANISM(S): Homo Sapiens 
2025-03-04 | PXD061425 |
MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
ProteomicsRegulation of eDHFR-tagged proteins with trimethoprim PROTACs
Temporal control of proteins in cells and living animals is crucial to improving the understanding of protein function in the post-genomic era. In addition, technologies that offer such control for engineered proteins could be used in therapeutic applications. Since regulation of proteins at a genom...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD045052 | Pride
Edhfr Degradation Protacs 
UnknownNon-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope.
Not available
S-EPMC9293674 | biostudies-literature
GenomicsEnhancement of ubiquitination-dependent mitophagy by unconventionally-acting PROTACs
Enhancement of ubiquitination-dependent mitophagy by unconventionally-acting PROTACs
PRJNA1074729 | ENA
ProteomicsProteomics Data for MDM2-targeting PROTACs in hBMSCs
Data files associated with the manuscript titled "Development of MDM2-targeting PROTAC for Advancing Bone Regeneration," which is currently under review. This manuscript introduces MDM2-targeting PROTACs customized for application in bone regeneration. We developed MDM2-PROTACs (CL144) that demonstr...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-12 | MSV000097106 | MassIVE
UnknownmRNA PROTACs: engineering PROTACs for high-efficiency targeted protein degradation.
Not available
S-EPMC10876204 | biostudies-literature
ProteomicsProteomics Data for MDM2-targeting PROTACs in MDM2-Overexpressing HeLa Cells
Data files associated with the manuscript titled "Development of MDM2-targeting PROTAC for Advancing Bone Regeneration," which is currently under review. This manuscript introduces MDM2-targeting PROTACs specifically designed for applications in bone regeneration. We developed MDM2-PROTACs (CL144) t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-12 | MSV000097107 | MassIVE
ProteomicsHomo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
E3 ubiquitin ligases are key enzymes within the ubiquitin proteasome system which catalyze the ubiquitination of proteins, targeting them for proteasomal degradation. E3 ligases are gaining importance as targets to small molecules, both for direct inhibition and to be hijacked to induce the degradat...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD007594 | Pride
E3 ligases  protacs  von hippel-lindau protein  protein degradation  chemical dimerizers. 
ProteomicsLinker-free PROTACs efficiently induce the degradation of oncoproteins
Linker-free PROTACs efficiently induce the degradation of oncoproteins
ORGANISM(S): Homo Sapiens 
2025-01-20 | PXD060001 |
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