Sort   by:  
 Page size 
MetabolomicsIntegrated multi-omics analysis of liver metabolic dysregulation in ACE2 knockout mice
This study systematically investigated the impact of ACE2 knockout (ACE2KO) on hepatic metabolic homeostasis and its molecular mechanisms, using integrated transcriptomic, proteomic, and metabolomic profiling. ACE2 deficiency exacerbates hepatic lipid accumulation, as evidenced by elevated total cho...
2025-06-23 | MTBLS12389 | MetaboLights
MetabolomicsXMulti-omics reveals zearalenone-induced hepato-intestinal injury and growth dysregulation in largemouth bass (Micropterus salmoides)
Zearalenone (ZEN), a prevalent Fusarium-derived mycotoxin in plant protein-based aquafeeds, poses severe threats to farmed aquatic animals. However, its toxic effects and underlying mechanisms on the commercially critical largemouth bass (Micropterus salmoides) remain largely uncharacterized. Here, ...
2026-05-05 | MTBLS14430 | MetaboLights
MetabolomicsDysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infec...
2023-02-01 | MTBLS6844 | MetaboLights
MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
MetabolomicsSARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals
Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces ...
2021-06-11 | MTBLS2840 | MetaboLights
MetabolomicsPP2Cm Dysregulation Is Associated with Impaired BCAA Catabolism and cGAS-STING Activation in Diabetic Kidney Disease
Background and Aims:Branched-chain amino acids (BCAAs) are increasingly implicated in diabetic kidney disease (DKD), yet the role of protein phosphatase 2C mitochondrial (PP2Cm), encoded by PPM1K and regulating BCAA catabolism through the branched-chain α-ketoacid dehydrogenase (BCKDH) complex, rema...
2026-10-09 | MTBLS15967 | MetaboLights
MetabolomicsThe Impact of Ethnicity and Intra-Pancreatic Fat on the Postprandial Metabolome Response to Whey Protein in Overweight Asian Chinese and European Caucasian Women with Prediabetes
The 'Thin on the Outside Fat on the Inside' TOFI_Asia study found Asian Chinese to be more susceptible to Type 2 Diabetes (T2D) compared to European Caucasians matched for gender and body mass index (BMI). This was influenced by degree of visceral adipose deposition and ectopic fat accumulation in k...
2022-10-12 | MTBLS5568 | MetaboLights
MetabolomicsMicrobiota-derived p-cresol and indole metabolites mediates neurotoxic gut-brain axis dysregulation in ALS
Integrated metabolomic profiling demonstrated a marked increase in microbiota-derived metabolites, particularly along aromatic amino acid pathways. Notably, p-cresol metabolites were significantly elevated in both brain and circulation, suggesting enhanced microbial phenylalanine/tyrosine metabolism...
2026-08-21 | MTBLS14404 | MetaboLights
MetabolomicsIntegrative analysis of gut microbiota, bile acid pathways, and immune dysregulation in dyslipidemia models_Bile acid profile of human fecal samples

Emerging evidence suggests a link between gut microbiota, bile acid metabolism, and immune dysregulation in dyslipidemia. Through a case-control study involving 140 participants and animal experiment, we identified significantly elevated count of peripheral blood CD3+ T cells, CD4+ T cells, CD8+ ...

2025-10-04 | MTBLS13093 | MetaboLights
MetabolomicsA multi-omics study on the metabolic reprogramming of a chlorophyll-deficient, high-protein Auxenochlorella pyrenoidosa mutant (CX41) generated by atmospheric and room temperature plasma (ARTP) mutagenesis.

This project aims to elucidate the molecular mechanism underlying the stable golden-yellow phenotype and enhanced protein accumulation in an Auxenochlorella pyrenoidosa mutant (CX41) generated by ARTP mutagenesis. Through comparative analysis between the wild-type (FACHB-9) and mutant s...

2025-12-26 | MTBLS13574 | MetaboLights
Sort   by:  
 Page size