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MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
MetabolomicsSemen Cuscutae flavonoids activated the cAMP-PKA-CREB-BDNF pathway and exerted an antidepressant effect in mice

Background: Semen Cuscutae flavonoids (SCFs) constitute a class of metabolites of Semen Cuscutae, a botanical drug that was recently found to have an anti-depression effect. This study aimed to evaluate the anti-depression effects of SCFs in chronic unpredi...

2025-05-12 | MTBLS11688 | MetaboLights
ProteomicsSmoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...
ORGANISM(S): Homo Sapiens 
2021-04-25 | PXD023893 | panorama
TranscriptomicsExploring the scope of TOR/PKA co-regulation in MDN
To identify genes co-regulated by TOR and PKA during growth in MDN BCY1, bcy1 deletion, TPK, and tpk1-3 deletion strains were grown in MDN with and without rapamycin treatment. Different combinations of these samples were examined.
ORGANISM(S): Saccharomyces cerevisiae 
2010-07-01 | E-GEOD-3160 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse S49 cells to study the global impact of cAMP and protein kinase A on gene expression
Although a substantial number of hormones and drugs increase cellular cAMP levels, the global impact of cAMP and its major effector mechanism, protein kinase A (PKA), on gene expression is not known. Here we show that treatment of wild-type S49 lymphoma cells for 24 h with 8-(4-chlorophenylthio)-cAM...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2413 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human ovarian cancer cells overexpressing PKA regulatory subunits
The regulatory subunit of cAMP-dependent protein kinase (PKA) exists in two isoforms, RI and RII, which distinguish the PKA isozymes, type I (PKA-I) and type II (PKA-II). Evidence obtained from a variety of different experimental approaches has shown that the relative levels of type I and type II PK...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12854 | biostudies-arrayexpress
GenomicsProtein Kinase A (PKA) inhibition in Saccharomyces cerevisiae and Kluyveromyces lactis
Protein Kinase A (PKA) inhibition in Saccharomyces cerevisiae and Kluyveromyces lactis
PRJNA687401 | ENA
TranscriptomicsExpression data from the mushroom bodies of Drosophila-PKA activity dependent manner
Temperature preference behavior in Drosophila depends on the level of PKA signaling in the mushroom bodies. To identify new components downstream to PKA, we carried out a genome-wide screen for genes regulated by PKA signaling in the mushroom bodies. Using the Gal4-UAS system, we increased or decrea...
ORGANISM(S): Drosophila melanogaster 
2014-03-25 | E-GEOD-28181 | biostudies-arrayexpress
ProteomicsH89 Phosphoproteomics in PKA-Null Cells
Protein phosphorylation plays a crucial role in propagating cellular responses to both internal and external cues. One of the most important kinases responsible for protein phosphorylation is protein kinase A (PKA). N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulphonamide (H89) is often used as a...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-28 | PXD011167 | Pride
Kinase inhibitor H89 Pka Phosphoproteomics 
TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress
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