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ProteomicsProteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates
Cancer metastasis causes approximately 90% of all cancer-related death. Independent of the advancement of cancer therapy, a majority of late stage patients suffers from metastatic cancer. Metastasis progresses by cancer cell migration and invasion throughout the body. This migration of cancer cells ...
ORGANISM(S): Homo sapiens (Human) 
2018-04-12 | PXD004658 | Pride
Breast cancer  metastasis  migration  pseudopodia  proteomics 
TranscriptomicsTranscription profiling of mouse pseudopodia AND cell bodies IN response TO LPA stimulation OR fibronectin
This SuperSeries is composed of the following subset Series:; GSE10226: Analysis of RNA distribution between pseudopodia and cell bodies in response to LPA stimulation; GSE10227: Analysis of RNA distribution between pseudopodia and cell bodies in response to Fibronectin Experiment Overall Design: Re...
ORGANISM(S): Mus musculus 
2008-04-05 | E-GEOD-10230 | biostudies-arrayexpress
TranscriptomicsLocalized Rho GTPase Activation Regulates RNA Dynamics and Compartmentalization in Tumor Cell Protrusions
mRNA trafficking and local protein translation are associated with protrusive cellular domains, such as neuronal growth cones, and deregulated control of protein translation is associated with tumor malignancy. We show here that activated RhoA, but not Rac1, is enriched in pseudopodia of MSV-MDCK-IN...
ORGANISM(S): Canis lupus familiaris 
2010-05-18 | E-GEOD-13253 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse migrating cell bodies vs pseudopodia fibronectin
The goal of the study was to identify on a genome-wide scale RNAs that are enriched at the leading edge of migrating cells. For this, we employed a fractionation method in which cells are plated on a microporous filter whose bottom side only is coated with fibronectin. The cells thus polarize and ex...
ORGANISM(S): Mus musculus 
2008-04-05 | E-GEOD-10227 | biostudies-arrayexpress
GenomicsPseudopodia couple microenvironmental sensing to adaptive transcriptional reprogramming
Pseudopodia couple microenvironmental sensing to adaptive transcriptional reprogramming
PRJNA1483720 | ENA
TranscriptomicsTranscription profiling of mouse pseudopodia and cell bodies in response to LPA stimulation
The goal of the study was to identify on a genome-wide scale RNAs that are enriched at the leading edge of migrating cells. For this, we employed a fractionation method in which serum-starved cells are first plated and allowed to spread on a microporous filter. Addition of LPA at the bottom side of ...
ORGANISM(S): Mus musculus 
2008-04-05 | E-GEOD-10226 | biostudies-arrayexpress
TranscriptomicsPseudopodia couple microenvironmental sensing to adaptive transcriptional reprogramming
Pseudopodia are actin-rich membrane extensions that allow cells to sense and respond to environmental cues, including hypoxia, inflammation, and chemotactic signals. Although these sensory structures are thought to transmit information from the cell periphery to the nucleus to regulate cell-state ch...
ORGANISM(S): Homo sapiens 
2026-07-31 | GSE337019 | GEO
UnknownThe local cell curvature guides pseudopodia towards chemoattractants.
Not available
S-EPMC2799990 | biostudies-literature
UnknownA model for a correlated random walk based on the ordered extension of pseudopodia.
Not available
S-EPMC2920832 | biostudies-literature
UnknownThe ordered extension of pseudopodia by amoeboid cells in the absence of external cues.
Not available
S-EPMC2668753 | biostudies-literature
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