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ProteomicsNEK1 autophosphorylation is disrupted by amyotrophic lateral sclerosis-associated missense variants: activity biomarkers and structural insights
Rare variants in NEK1, encoding a serine/threonine kinase, are established contributors to amyotrophic lateral sclerosis (ALS), but the biochemical effects of ALS-associated NEK1 missense variants on kinase activity have not been directly investigated. This project maps the phosphorylation landscape...
ORGANISM(S): Homo sapiens (Human) 
2026-09-02 | PXD079815 | Pride
Nek1 kinase  autophosphorylation  amyotrophic lateral sclerosis  als  motor neuron disease  phosphoproteomics  phosphorylation  kinase activity  activation loop  pthr156  pser14  pser418  lc-ms/ms  hcd  ethcd  u-2 os cells  gfp immunoprecipitation  kinase-dead mutant  missense variants 
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