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GenomicsInflammatory response in HSPC of PTPN11-mutated JMML
Inflammatory response in HSPC of PTPN11-mutated JMML
PRJNA759790 | ENA
TranscriptomicsRNA-seq Analysis of Wild Type and Ptpn11-deficient cerebellar Transcriptomes
We have recently discovered that deletion of Ptpn11, which codes for protein tyrosine phosphatase Shp2, blocks Bergmann glia (BG) formation and cerebellar foliation, whereas expressing a constitutively active Mek1 (Map2k1), Mek1DD, reverses the Ptpn11-deficient phenotypes, uncovering a previously un...
ORGANISM(S): Mus musculus 
2017-05-10 | GSE87104 | GEO
TranscriptomicsInflammatory response in HSPC of PTPN11-mutated JMML
Activating mutations in PTPN11 gene are the most frequent in JMML patients. Here we explore the transcriptome of HSPC (hematopoietic stem and progenitor cells) sorted from sporadic JMML patients with PTPN11 mutation and from healthy age matched donnors. Bulk transcriptome of sorted HSPC reveals an i...
ORGANISM(S): Homo sapiens 
2021-09-06 | GSE183252 | GEO
GenomicsExpression data from mouse MLL/AF10(OM-LZ) myeloid leukemia cells harboring wild-type KRAS, KRAS-G12C, wild-type PTPN11, PTPN11-G503A, without or with Hoxa11
Expression data from mouse MLL/AF10(OM-LZ) myeloid leukemia cells harboring wild-type KRAS, KRAS-G12C, wild-type PTPN11, PTPN11-G503A, without or with Hoxa11
PRJNA555634 | ENA
TranscriptomicsMurine mesenchymal stem/progenitor cells (MSPC): Ptpn11+/+ MSPC vs. Ptpn11E76K/+ MSPC
Transcriptional profiling of mouse mesenchymal stem/progenitor cells (MSPC) comparing control Ptpn11+/+ MSPC with Ptpn11E76K/+ MSPC. By obtaining 20 million reads of sequence from two pair, we confirmed our cytokine/chemokine array data and quantitative ELISA data from both mouse and patient-derived...
ORGANISM(S): Mus musculus 
2017-08-25 | GSE81311 | GEO
TranscriptomicsExpression data from mouse MLL/AF10(OM-LZ) myeloid leukemia cells harboring wild-type KRAS, KRAS-G12C, wild-type PTPN11, PTPN11-G503A, without or with Hoxa11
Cooperation of MLL/AF10 with RAS pathway mutations accelerated myeloid leukemia development. The detail molecular mechanism is analyzed by identification of the differentially expressed genes between MLL/AF10 cells harboring wild-type and mutant RAS pathway genes and by with or without Hoxa11. We us...
ORGANISM(S): Mus musculus 
2020-07-01 | GSE134586 | GEO
UnknownLeukemogenic Ptpn11 allele causes defective erythropoiesis in mice.
Not available
S-EPMC4188809 | biostudies-literature
UnknownLoss of Ptpn11 (Shp2) drives satellite cells into quiescence.
Not available
S-EPMC5441871 | biostudies-literature
GenomicsExome sequencing identifies PTPN11, PDGFRB, KRAS, and NRAS mutations in TKI resistance inhibitor-resistance cell line models with acquired mutations in PTPN11, PDGFRB, KRAS, and NRAS: Lessons from in vitro-models
Exome sequencing identifies PTPN11, PDGFRB, KRAS, and NRAS mutations in TKI resistance
PRJEB60565 | ENA
UnknownUnderstanding Molecular Basis of PTPN11-Related Diseases.
Not available
S-EPMC12754711 | biostudies-literature
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