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GenomicsTET2_x001E_mediated PTPN6 demethylation drives post_x001E_burn immune paralysis and AAV_x001E_CRISPRi targeting PTPN6 improves secondary bloodstream infection outcome
TET2_x001E_mediated PTPN6 demethylation drives post_x001E_burn immune paralysis and AAV_x001E_CRISPRi targeting PTPN6 improves secondary bloodstream infection outcome
PRJNA1451243 | ENA
GenomicsPtpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
PRJNA578780 | ENA
TranscriptomicsDeficiency in hematopoietic phosphatase Ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos
Deficiency in the protein-tyrosine phosphatase SHP1/PTPN6 is linked with hematological malignancies and chronic inflammatory diseases. Here we exploited the embryonic and larval stages of zebrafish as an animal model to study ptpn6 function in the sole context of innate immunity. We show that ptpn6 ...
ORGANISM(S): Danio rerio 
2012-12-31 | E-GEOD-34930 | biostudies-arrayexpress
GenomicsCharacterization of cellular responses of Ptpn6 (SHP-1) cKO in hippocampus by scRNA-seq
Characterization of cellular responses of Ptpn6 (SHP-1) cKO in hippocampus by scRNA-seq
PRJNA1374068 | ENA
TranscriptomicsTET2_x001E_mediated PTPN6 demethylation drives post_x001E_burn immune paralysis and AAV_x001E_CRISPRi targeting PTPN6 improves secondary bloodstream infection outcome
Background Severe burn injury often leads to a state of immune paralysis, which markedly increases the risk of death from secondary bloodstream infection. However, the molecular mechanisms underlying post_x001E_burn immune paralysis, especially why it worsens infectious outcomes, remain poorly under...
ORGANISM(S): Mus musculus 
2026-04-30 | GSE327575 | GEO
TranscriptomicsPtpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation
Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune disease and IL-1R-dependent caspase-1-independent inflammatory disease. Conditional deletion of Ptpn6 in neutrophils (Ptpn6∆PMN) is sufficient to initiate IL-1R-dependent cutaneous inflammatory disease, but the source of IL-1 an...
ORGANISM(S): Mus musculus 
2019-11-12 | GSE139223 | GEO
GenomicsHuman-relevant Ptpn6 mutation alters immune and hepatic functions during aging
Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging
PRJNA1365010 | ENA
TranscriptomicsGene Expression Profile of Motheaten Mice (meb2) with novel mutation in Ptpn6 gene.
Gene expression array utilizes the advantage of the big number of the significantly changed genes creating transcriptional profiles of known mutations. Creating gene expression profiles of the animal models with known genetic defect provides great opportunity for further investigation human diseases...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-17161 | biostudies-arrayexpress
UnknownPtpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation.
Not available
S-EPMC6923591 | biostudies-literature
GenomicsBone marrow derived macrophage response to CSF1R stimulation or starvation after deletion of Ptpn6 or Rraga
Bone marrow derived macrophage response to CSF1R stimulation or starvation after deletion of Ptpn6 or Rraga
PRJNA1375773 | ENA
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