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ProteomicsProteomic profiling of mouse brain pyruvate kinase binding proteins: a hint for moonlighting functions of PKM1?
Affinity based proteomic profiling is widely used for identification of proteins involved in for-mation of various interactomes. Pyruvate kinase (PK), a classical glycolytic enzyme catalyzing the last step of glycolysis, exists in four isoforms, one of which, PKM2; pyruvate kinase muscle isoform M2 ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD041321 | Pride
Pyruvapyruvate kinase  pyruvate kinase isoforms  pkm  non-canonical moonlighting functions  pkm-binding proteins  interactomete kinase  pyruvate kinase isoforms  pkm  non-canonical moonlighting functions  pkm-binding proteins  interactome 
MetabolomicsTargeted metabolomic analysis in hepatic extracts, serum, and urine of female mice gavaged with TCDD every 4 days for 28 days
TCDD is an environmental contaminant that elicits a number of hepatic effects including fat accumulation, inflammation, and fibrosis that can progress to hepatocellular carcinoma. RNA-Seq and targeted metabolomics were integrated with complementary dioxin response element (DRE) location and aryl hyd...
2017-02-02 | MTBLS225 | MetaboLights
TranscriptomicsExpression data from PKM1 or PKM2 expressing mouse embryonic fibroblasts.
We profiled global gene expression for two separate lines of mouse embryonic fibroblasts and find that deletion of PKM2 and expression of PKM1 does not alter global gene expression profiles. We used microarrays to futher characterize the effects of PKM1 expression compared to PKM2 expression on glob...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-60499 | biostudies-arrayexpress
UnknownDistinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.
Not available
S-EPMC2871385 | biostudies-literature
UnknownOrgan-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms.
Not available
S-EPMC4342556 | biostudies-literature
ProteomicsPyruvate kinase variant of fission yeast reprograms energy metabolism triggering systemic changes in cell regulation, growth and stress resistance
Cells balance glycolysis with respiration to support their energetic and biosynthetic needs in different environmental or physiological contexts. With abundant glucose, many cells prefer to grow by fermentation. Using 161 natural isolates of fission yeast, we investigated the genetic basis and pheno...
ORGANISM(S): Schizosaccharomyces pombe 972h- 
2020-05-27 | PXD017833 | Pride
Fermentation Oxidative stress S. pombe Glycolysis 
UnknownPyruvate kinase: Function, regulation and role in cancer.
Not available
S-EPMC4662905 | biostudies-literature
UnknownAerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms.
Not available
S-EPMC7203425 | biostudies-literature
UnknownOleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms.
Not available
S-EPMC3953484 | biostudies-literature
UnknownMuscle-specific pyruvate kinase isoforms, PKM1 and PKM2, regulate mammalian SWI/SNF proteins and histone 3 phosphorylation during myoblast differentiation.
Not available
S-EPMC11268309 | biostudies-literature
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