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ProteomicsRAB GTPase proximity interactome
RAB GTPases represent the most abundant family of small GTPases and regulate multiple aspects of membrane trafficking events, from cargo sorting to vesicle budding, transport, docking, and fusion. To control these processes, RABs are tightly regulated by guanine exchange factors (GEFs) and GTPase-ac...
ORGANISM(S): Homo sapiens (Human) 
2025-12-02 | PXD057404 | Pride
Rab gtpase Apex2 Membrane trafficking Bioid 
GenomicsNKX3-1, a Novel Transcriptional Factor of AR, Promotes Prostate Cancer Cell Survival via RAB3B GTPase-mediated protein trafficking
Androgen receptor (AR) orchestrates an intricate transcriptional regulatory network that governs prostate cancer initiation, development and progression. To understand this network in detail, we generated genome-wide maps of AR occupancy by ChIP-seq in LNCaP cells. We found NKX3-1, an androgen-depen...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-28264 | biostudies-arrayexpress
UnknownCrystal structure of TBC1D15 GTPase-activating protein (GAP) domain and its activity on Rab GTPases.
Not available
S-EPMC5368074 | biostudies-literature
UnknownInsulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation.
Not available
S-EPMC2781555 | biostudies-literature
TranscriptomicsTranscription profiling of peripheral blood or primary finroblast cultures from choroideremia patients to determine if loss-of-function mutations in REP-1 affect intracellular vesicle transport in fibroblasts and monocytes of CHM patients
Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs. Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicu...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-17549 | biostudies-arrayexpress
UnknownYeast rab GTPase-activating protein Gyp1p localizes to the Golgi apparatus and is a negative regulator of Ypt1p.
Not available
S-EPMC34579 | biostudies-literature
UnknownThe Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan.
Not available
S-EPMC9371356 | biostudies-literature
UnknownRecessive Inactivating Mutations in TBCK, Encoding a Rab GTPase-Activating Protein, Cause Severe Infantile Syndromic Encephalopathy.
Not available
S-EPMC4833196 | biostudies-literature
UnknownLate blight pathogen targets host Rab-G3 GTPases with an atypical GTPase-activating protein.
Not available
S-EPMC12315501 | biostudies-literature
UnknownE50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.
Not available
S-EPMC3994150 | biostudies-literature
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