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TranscriptomicsPositive and negative regulation of lymphomagenesis by the NF-kappaB subunit c-Rel
'The REL gene, encoding the NF-κB subunit c-Rel, is frequently amplified in B-cell lymphoma and functions as a tumour promoting transcription factor. Here we report the surprising result that c-rel -/- mice display significantly earlier lymphomagenesis in the c-Myc driven, Eμ-Myc model of B-cell lym...
ORGANISM(S): Mus musculus 
2014-12-31 | E-MTAB-2774 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila mutant for transcription factors Dorsal, Dif, and Relish and their effect on immune response
The abstract of the manuscript titled "Microarray analyses reveal possible new targets for the Rel protein Dif in Drosophila melanogaster " is given below: ; The fruit fly Drosophila melanogaster express three closely related NF-κB-like transcription factors: Dorsal, Dif, and Relish. They share sig...
ORGANISM(S): Drosophila melanogaster 
2008-06-13 | E-GEOD-5489 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Hodgkin Lymphoma cell line following REL-B depletion
The expression array data will be merged with Rel-B ChIP-Seq data in HL cell lines. This will show REL-B direct and indirect controlled downstream target genes HL cells were infected with a retrovirus that delivers a specific shRNA sequence to knock down the expression of REL-B
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-35224 | biostudies-arrayexpress
TranscriptomicsIdentification of c-Rel and RelA binding regions in stimulated EL4 cells
c-Rel and RelA are members of the NF-kappaB family of transcription factors. They both have important roles in T cell activation. To discover where in the genome c-Rel and RelA bind and hence which genes they may directly target, we used ChIP-chip with EL4 cells stimulated with phorbol ester (PMA) a...
ORGANISM(S): Mus musculus 
2013-12-29 | E-GEOD-42818 | biostudies-arrayexpress
TranscriptomicsMicroarray of bone marrow-derived macrophages (BMDMs) from wild-type and Rel knockout mice
Bone marrow-derived macrophages were generated from bone marrow of naive WT or Rel-/- mice. After red blood cell lysis, BM cells were cultured in L929-conditioned medium for 7 days. After lipopolysaccharide (100 ng/mL) stimulation, RNAs were collected for microarray.
ORGANISM(S): Mus musculus 
2020-03-10 | E-MTAB-8714 | biostudies-arrayexpress
TranscriptomicsCharacterization of the RelBbu regulon in Borrelia burgdorferi reveals modulation of glycerol metabolism by (p)ppGpp
The bacterial stringent response is triggered by deficiencies of available nutrients andother environmental stresses. It is mediated by 5'-triphosphate-guanosine-3'- diphosphate and 5'-diphosphate-guanosine-3'-diphosphate (collectively (p)ppGpp) and generates global changes in gene expression and me...
ORGANISM(S): Borrelia burgdorferi 
2015-01-30 | E-MTAB-3029 | biostudies-arrayexpress
ProteomicsRegulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway C4PR_LIV
The ATR-CHK1 signalling pathway responds to single strand DNA breaks and is required for cancer cells to survive the high levels of DNA replication stress and genomic instability resulting from the activity of oncogenes such as MYC. For this reason, inhibitors of CHK1 have great potential as anti-c...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-19 | PXD026203 | Pride
Sps-ms3 Mouse Tmt Phosphorylation Lc-ms/ms 
GenomicsIdentification of suppressor mutations in rel mutants in Synechococcus elongatus PCC7942
Suppressor mutations in Synechococcus rel mutants
PRJEB110973 | ENA
GenomicsStepwise Neofunctionalization of c-Rel during Vertebrate Evolution (ChIP-Seq)
Stepwise Neofunctionalization of c-Rel during Vertebrate Evolution (ChIP-Seq)
PRJNA1015721 | ENA
Genomicsc-Rel-dependent monocytes are potent immune suppressor cells in cancer
c-Rel-dependent monocytes are potent immune suppressor cells in cancer
PRJNA846321 | ENA
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