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ProteomicsIntegrated omic analysis reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock
Circadian rhythmicity in renal function suggests a requirement for circadian adaptations in renal metabolism. We studied circadian changes in renal metabolic pathways using integrated transcriptomic, proteomic and metabolomic analysis performed on control mice and mice deficient in the circadian clo...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-15 | PXD036803 | Pride
Mouse kidney  control mice  mice ko for arntl in the renal tubule  renal circadian proteome 
ProteomicsCircadian Gene Expression in Mouse Renal Proximal Tubule
Circadian variability in kidney function has long been recognized but is often ignored as a potential confounding variable in in vivo physiological experiments. To provide a guide for physiological studies on the kidney proximal tubule, we have now created a data resource consisting of expression le...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-10 | PXD039006 | Pride
Circadian variation Proteomics Proximal tubule Transcriptomics 
UnknownCircadian gene expression in mouse renal proximal tubule.
Not available
S-EPMC9988533 | biostudies-literature
ProteomicsUrinary Proteome of Chronic Kidney Disease of Unknown Etiology (CKDu)
2 mL of preserved urine samples were precipitated overnight with 5 mL of ice-cold acetone, pellets were washed 70% acetone resuspended in 5% SDS followed by trypsin digestion of up to 100 ugs of each sample using an S-trap. One-third of tryptic peptides were microflow LC-MS/MS using an ACQUITY UPLC ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-11 | MSV000090513 | MassIVE
GenomicsDietary Salt Impairs Circadian Physiological Metabolic Adaptations in Salt-Sensitive Hypertension
Dietary Salt Impairs Circadian Physiological Metabolic Adaptations in Salt-Sensitive Hypertension
PRJNA1370932 | ENA
TranscriptomicsDietary Salt Impairs Circadian Physiological Metabolic Adaptations in Salt-Sensitive Hypertension
The body's circadian rhythm is coordinated by a central hypothalamic and peripheral molecular clocks, which involve clock proteins (PER, CRY, CLOCK, and BMAL1). Our recent study demonstrated that deletion of Per1 in Dahl salt-sensitive (SS) rats (SSPer1-/-) exacerbated SS hypertension (HTN), kidney ...
ORGANISM(S): Rattus norvegicus 
2025-12-01 | GSE311806 | GEO
ProteomicsCold Storage Disrupts the Proteome Landscape in Rat Kidney Transplants
Approximately 70% of kidney grafts are obtained from deceased donors, and these grafts must be preserved in hypothermic conditions to prolong their viability until transplantation. However, prolonged cold storage (CS) of kidneys results in poor long-term outcomes after transplantation. We reported p...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2024-04-18 | MSV000094566 | MassIVE
TranscriptomicsMicroarray profiling reveals broad and differential effects of RBM3 on miRNA expression.
MicroRNAs (miRNAs) are a family of short, noncoding RNAs that regulate translation of mRNAs by mechanisms involving the binding of complementary sequences. The influence of miRNAs on the proteome and cellular events is extensive as they regulate an estimated 60% of the transcriptome and play key ro...
ORGANISM(S): Mus musculus 
2011-11-10 | E-GEOD-33519 | biostudies-arrayexpress
ProteomicsDynamic profiling of the protein life cycle in response to pathogens (protein)
Protein expression is regulated by production and degradation of mRNAs and proteins, but their specific relationships remain unknown. We combine measurements of protein production and degradation and mRNA dynamics to build a quantitative genomic model of the differential regulation of gene expressio...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-59792 | biostudies-arrayexpress
ProteomicsImpact of exercise on the proteome of human peripheral blood mononuclear cells
This project aimed to characterize the impact of high-intensity interval exercise (HIIE) vs. moderate-intensity continuous exercise (MICE) on immune cell proteomics. In a randomized crossover study with 23 young, recreationally active runners, we isolated peripheral blood mononuclear cells (PBMCs) b...
ORGANISM(S): Homo sapiens (Human) 
2025-01-25 | PXD058573 | Pride
Exercise 
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