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MetabolomicsImmunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains uncl...
2023-05-02 | MTBLS5288 | MetaboLights
TranscriptomicsGene expression signatures of symptomatic respiratory viral infection in adults
Diagnosis of acute respiratory viral infection is currently based on clinical symptoms and pathogen detection. Use of host peripheral blood gene expression data to classify individuals with viral respiratory infection represents a novel means of infection diagnosis. We used microarrays to capture p...
ORGANISM(S): Homo sapiens 
2009-08-06 | E-GEOD-17156 | biostudies-arrayexpress
MetabolomicsAttenuate host susceptibility to respiratory virus invasion by inhibiting interactions between host proteins SLC16A3 and AP1G1

Modulating cell endocytosis activity to reduce host susceptibility to virus represents a promising strategy for antiviral drug development. In this study, we reveal that lactate transporter SLC16A3 as a critical host factor for reducing diverse virus invasion. By performing metabolomics, proteomi...

2025-07-28 | MTBLS12788 | MetaboLights
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
TranscriptomicsGene expression changes induced by MV130 (Bactek®) in human monocytes-derived dendritic cells.
MV130 is a commercially polyvalent bacterial preparation, which has shown to reduce the the rate of respiratory infections in patients suffering from recurrent respiratory tract infections. However, the immunological mechanisms associated to this clinical benefit remain unknown. We wanted to identif...
ORGANISM(S): Homo sapiens 
2017-12-14 | E-MTAB-5259 | biostudies-arrayexpress
ProteomicsSystematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights Into Pathogenesis Of RSV-Induced Lower Respiratory Tract Infections
Lower respiratory tract infections (LRTI) from human Respiratory Syncytial Virus (RSV) are a significant cause of morbidity in children. A component of LRTI pathogenesis is due to signals generated by infected lower airway cells that alter lymphocyte populations and trigger airway remodeling. To ob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080867 | MassIVE
TranscriptomicsHost transcriptional response to influenza and other acute respiratory viral infections – a prospective cohort study
The purpose of the study was to assess the patterns of global gene expression in peripheral blood cells and uncover the complex dynamics of host response to ARIs such as pandemic H1N1. To understand the molecular bases and network orchestration of host responses, we prospectively enrolled 1610 heal...
ORGANISM(S): Homo sapiens 
2015-04-28 | E-GEOD-68310 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human blood leukocytes to discriminate patients with acute infections
Each infectious agent represents a unique combination of pathogen-associated molecular patterns that interact with specific pattern-recognition receptors expressed on immune cells. Therefore, we surmised that the blood immune cells of individuals with different infections might bear discriminative t...
ORGANISM(S): Homo sapiens 
2009-03-13 | E-GEOD-6269 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling is Superior to Procalcitonin to Discriminate Bacterial vs. Viral Lower Respiratory Tract Infections in Hospitalized Adults
Background: Distinguishing between bacterial and viral lower respiratory tract infections (LRTI) in hospitalized patients remains challenging. Transcriptional profiling is a promising tool for improving diagnosis in LRTI. Methods: We performed whole blood transcriptional analysis in a cohort of ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-60244 | biostudies-arrayexpress
ProteomicsBovine Respiratory Disease Complex
Bovine respiratory epithelial cells have different susceptibility to bovine respiratory syncytial virus infection. The cells derived from the lower respiratory tract were significantly more susceptible to the virus than those derived from the upper respiratory tract. Pre-infection with virus of lowe...
ORGANISM(S): Bos Taurus 
2020-07-28 | PXD019509 | JPOST Repository
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