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TranscriptomicsGlobal gene expression changes in rat retinal ganglion cells after experimental glaucoma
Goals of the study: 1. Assess the gene expression profile in rat RGC after experimental IOP elevation to elucidate the molecular mechanisms of RGC death. 2. Identify potentially novel genes and pathways that may contribute to RGC death in glaucoma. Background: Glaucoma is a neurodegenerative diseas...
ORGANISM(S): Rattus norvegicus 
2010-10-01 | E-GEOD-12596 | biostudies-arrayexpress
UnknownCirculating Small Extracellular Vesicles Involved in Systemic Regulation Respond to RGC Degeneration in Glaucoma.
Not available
S-EPMC11348076 | biostudies-literature
ProteomicsDifferential retinal protein expression in primary and secondary retinal ganglion cell degeneration identified by integrated SWATH and target-based proteomics
To investigate the retinal proteins associated with primary and secondary retinal ganglion cell (RGC) degeneration and explore their molecular pathways, SWATH label-free and target-based mass spectrometry was employed to identify the proteomes in various retinal locations in response to localized op...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-07 | PXD026783 | Pride
Ganglion cell Mass spectrometry Neurodegeneration Optic nerve Protein 
UnknownGPX4 Promotes Optic Nerve Regeneration and RGC Neuroprotection.
Not available
S-EPMC12157684 | biostudies-literature
UnknownYthdf2 Ablation Protects Aged Retina From RGC Dendrite Shrinking and Visual Decline.
Not available
S-EPMC12266746 | biostudies-literature
TranscriptomicsAldose reductase inhibition decelerates optic nerve degeneration by suppressing retinal microglia activation
To investigate the role of aldose reductase (AR) inhibition using Sorbinil on retinal microglia (RMG) activation, retinal ganglion cell (RGC) survival, and axon regeneration after optic nerve trauma. We observed that AR inhibition using Sorbinil attenuates RMG activation and subsequently promotes RG...
ORGANISM(S): Mus musculus 
2023-04-05 | GSE200233 | GEO
GenomicsAldose reductase inhibition decelerates optic nerve degeneration by suppressing retinal microglia activation
Aldose reductase inhibition decelerates optic nerve degeneration by suppressing retinal microglia activation
PRJNA823714 | ENA
ProteomicsProteomic characteristics in degenerated and regenerative mouse retina
The retina constitutes a segment of the central nervous system (CNS). Both retinal and CNS neurons lack the inherent capacity to spontaneously regenerate axons following injury. Retinal ganglion cells (RGCs) serve as the neurons connecting the eyes to the brain. Diseases such as glaucoma initiate da...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-29 | PXD049992 | Pride
Regeneration  glaucoma  rgc degeneration  dia-ms 
UnknownSimultaneous generation of transplantable RGC-like and corneal progenitor cells from hiPSCs using a dual-lineage platform.
Not available
S-EPMC12837101 | biostudies-literature
UnknownGSK840 Alleviates Retinal Neuronal Injury by Inhibiting RIPK3/MLKL-Mediated RGC Necroptosis After Ischemia/Reperfusion.
Not available
S-EPMC10691386 | biostudies-literature
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