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ProteomicsRNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential.
RNF185 is a RING finger domain-containing ubiquitin ligase implicated in ER-associated degradation. Prostate tumor patient data analysis revealed a negative correlation between RNF185 expression and prostate cancer progression and metastasis. Likewise, several prostate cancer cell lines exhibited gr...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD045473 | Pride
Ubiquitin ligase  rnf185  prostate adenocarcinoma  metastasis  epithelial-mesenchymal transition (emt)  collagen 
ProteomicsThe RNF185/Membralin ubiquitin ligase complex is a new ERAD branch involved in the degradation of a distinct subset of integral membrane proteins.
The endoplasmic reticulum-associated degradation (ERAD) pathway is responsible for ubiquitin-mediated quality control of secretory and ER-resident proteins. In the present study, two short-lived ER integral membrane model proteins were used to screen a genome-wide CRISPR-Cas9 library, resulting in t...
ORGANISM(S): Homo sapiens (Human) 
2020-08-03 | PXD018517 | Pride
Endoplasmic reticulum-associated degradation (erad)  e3 ligase rnf185  membralin  tmem259  tmub1  tmub2  ubiquitin 
ProteomicsTapasin assembly surveillance by the RNF185/MBRL ubiquitin ligase complex regulates MHC-I antigen presentation
Immune surveillance by cytotoxic T cells eliminates tumor cells and cells infected by intracellular pathogens. This process relies on the presentation of antigenic peptides on Major Histocompatibility Complex class I (MHC-I) at the cell surface. The loading of these peptides onto MHC-I depends on t...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-09-17 | PXD048728 | Pride
Rnf185 mbrl tapasin 
GenomicsRNF185 control of COL3A1 expression impacts prostate cancer migration and metastatic potential
RNF185 control of COL3A1 expression impacts prostate cancer migration and metastatic potential
PRJNA952534 | ENA
TranscriptomicsRNF185 control of COL3A1 expression limits prostate cancer migration and metastatic potential
RNF185 is a RING finger domain-containing ubiquitin ligase implicated in ER-associated degradation. Prostate tumor patient data analysis revealed a negative correlation between RNF185 expression and prostate cancer progression and metastasis. Likewise, several prostate cancer cell lines exhibited gr...
ORGANISM(S): Homo sapiens 
2023-10-18 | GSE245708 | GEO
TranscriptomicsRNF185 control of COL3A1 expression impacts prostate cancer migration and metastatic potential
RNF185 is a RING finger domain-containing ubiquitin ligase implicated in ER associated degradation. Analysis of prostate tumor patient data revealed a negative correlation between RNF185 expression and prostate cancer progression and metastasis. Likewise, several prostate cancer cell lines exhibited...
ORGANISM(S): Mus musculus 
2024-02-14 | GSE228999 | GEO
TranscriptomicsGene silencing of BSK65-MONO1 (RNF185) and of its natural antisense RNA (RNF185-AS) using siRNAs
Microarray profiles of native HeLa cells and RNF185/BSK65 gene silenced HeLa cells using siRNAs LMG2 and LMG4 were monitored using Affymetrix U133 Plus 2.0 microarrays.
ORGANISM(S): Homo sapiens 
2013-06-07 | GSE47685 | GEO
UnknownRNF185 Control of COL3A1 Expression Limits Prostate Cancer Migration and Metastatic Potential.
Not available
S-EPMC10841372 | biostudies-literature
UnknownThe E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.
Not available
S-EPMC5358892 | biostudies-literature
TranscriptomicsGene silencing of BSK65-MONO1 (RNF185) and of its natural antisense RNA (RNF185-AS) using siRNAs
Microarray profiles of native HeLa cells and RNF185/BSK65 gene silenced HeLa cells using siRNAs LMG2 and LMG4 were monitored using Affymetrix U133 Plus 2.0 microarrays. Two independent microarray assays of each analysis were used for the comparison of native vs. siRNA treated HeLa cells with LMG2 an...
ORGANISM(S): Homo sapiens 
2013-06-07 | E-GEOD-47685 | biostudies-arrayexpress
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