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We identified two novel transcription factors ‘Triterpene Saponin Activation Regulator’ (TSAR) 1 and 2 that each activate a specific branch of saponin synthesis in M. truncatula. Therefore we generated three independent TSAR1 and three independent TSAR2 overexpression (OE) hairy root lines. As a con...
ORGANISM(S): Medicago truncatula 
TSAR1 and TSAR2 activate triterpene saponin production in Medicago truncatula
Cell suspensions were treated with yeast elicitor (pathogen) or methyl jasmonate (wounding signal) and harvested at 2 and 24 hour time points in order to compare the transcriptomics between them in early and late response.
ORGANISM(S): Medicago truncatula 
Saponin-based vaccine adjuvants are potent in preclinical animal models and humans, but their mechanisms of action remain poorly understood. Using a stabilized HIV envelope trimer as a model immunogen, we carried out studies in non-human primates (NHPs), comparing the most common clinical adjuvant a...
ORGANISM(S): Macaca mulatta 
2024-07-01 | GSE264685 | GEO

Paris polyphylla var. yunnanensis is a widely cultivated rhizomatous perennial woody plant known for producing the highly valued steroidal saponins. Steroidal saponins serve as the primary active component and exhibit a variety of pharmacological effects. However, the accumulation of secondary me...

2025-03-13 | MTBLS10683 | MetaboLights
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