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GenomicsMLL1 is essential for the senescence-associated secretory phenotype
This SuperSeries is composed of the SubSeries listed below. Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory respon...
ORGANISM(S): Homo sapiens 
2016-02-22 | E-GEOD-78142 | biostudies-arrayexpress
GenomicsMLL1 is essential for the senescence-associated secretory phenotype [ChIP-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78141 | biostudies-arrayexpress
ProteomicsCharacterization of intact proteomic profile of senescent-associated secretory phenotype (SASP) by top-down mass spectrometry.
Senescent cells are increasingly recognized as major contributors to age-related diseases, primarily through the secretion of bioactive molecules known as the senescence-associated secretory phenotype (SASP). The SASP plays a crucial role in promoting various age-related conditions, including neurod...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD061829 | Pride
Senescence  aging  top-down proteomics  proteoforms  biomarkers  sasp  senescence-associated secretory phenotype 
TranscriptomicsMLL1 is essential for the senescence-associated secretory phenotype [RNA-Seq]
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the se...
ORGANISM(S): Homo sapiens 
2016-02-23 | E-GEOD-78138 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of xCT-mediated regulatory network: identification of novel targets against AIDS-associated lymphoma
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of primary effusion lymphoma (PEL), a rapidly progressing malignancy mostly arising in HIV-infected patients. Even under conventional chemotherapy, PEL continues to portend nearly 100% mortality within several months, which ur...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-65418 | biostudies-arrayexpress
GenomicsSASP Suppression by hTSCs Secretome
SASP Suppression by hTSCs Secretome
PRJNA1186722 | ENA
GenomicsSASP-related signals and SASP gene expression profiles in senescent cells after 18β-GA treatment.
SASP-related signals and SASP gene expression profiles in senescent cells after 18β-GA treatment.
PRJNA1106921 | ENA
GenomicsMitochondrial RNA cytosolic leakage drives the SASP
Mitochondrial RNA cytosolic leakage drives the SASP
PRJNA1312484 | ENA
GenomicsMitochondrial metabolism and epigenetic crosstalk drive the SASP (Multiome)
Mitochondrial metabolism and epigenetic crosstalk drive the SASP (Multiome)
PRJNA1434289 | ENA
GenomicsMitochondrial RNA cytosolic leakage drives the SASP [CRISPR/Cas9]
Mitochondrial RNA cytosolic leakage drives the SASP [CRISPR/Cas9]
PRJNA1314047 | ENA
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