The microarray study was used to compare the gene expression profile of EDL933 in LB, sdhA deletion mutant in LB, and sdhA deletion mutant in LB with 2.5 mM Fumaric acid.
ORGANISM(S): Escherichia coli O157:H7 Escherichia coli O157:H7 str. EDL933
Mitochondrial dysfunction and redox imbalance are key drivers of metabolic dysfunction-associated steatohepatitis (MASH), yet therapeutic strategies targeting mitochondrial respiratory integrity remain limited. We identified succinate dehydrogenase subunit A (SDHA) as a direct functional target of t...
Background & Aims: Succinate dehydrogenase enzyme (SDH) is frequently found to be diminished in Hepatocellular carcinoma (HCC) patient samples, and SDH reduction is associated with elevated succinate level and poor prognosis in HCC patients. But the underlying mechanisms about how impaired SDH activ...
