Sort   by:  
 Page size 
MetabolomicsBMAL1-depletion remodels ceramide metabolism to regulate ferroptosis and sorafenib chemosensitivity in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. We discovered that BMAL1 is a ferroptosis suppressor. Furthermore, it was also found to be overexpressed in AML patients, affecting the cell cycle and promoting tumor cell growth and progression. In this study, we furthe...
2025-01-24 | MTBLS11557 | MetaboLights
GenomicsIntegrative epigenomic analysis in MLL-AF9 acute myeloid leukemia (AML) and B-acute lymphoblastic leukemia (B-ALL)
Next generation DNA sequencing of acute myeloid leukemia (AML) patient samples has revealed novel recurrent mutations while at the same time highlighting the genetic heterogeneity of the disease. These observations suggest that an extraordinarily large number of combinations of mutations can contrib...
ORGANISM(S): Homo sapiens 
2017-05-02 | E-GEOD-70755 | biostudies-arrayexpress
TranscriptomicsDNA copy number analysis from mice with radiation-induced acute myeloid leukemia
Certain mouse strains such as CBA, C3H and RFM, have high incidence of radiation-induced acute myeloid leukemia (AML). The data in this serie was generated by using spleen DNA from CBA mice which were irraidated with either gamma-rays or heavy ion (HZE) particles. Spleen DNA with radiation-induced A...
ORGANISM(S): Mus musculus 
2012-10-05 | E-GEOD-37233 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation in MDS/secondary AML and de novo AML
An increasing body of work reveals aberrant hypermethylation of genes occurring in and potentially contributing to the pathogenesis of myeloid malignancies. Several of these diseases, such as myelodysplastic syndromes (MDS), are responsive to DNA methyltransferase inhibitors. In order to determine ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-17328 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse leukemia cells induced by HoxA10 forced expression - experiment 2
The Rosa-rtTAnls/tetO-HoxA10 mouse model is a Tetracycline-On (tetO) system in which the expression level of HoxA10 can be tightly regulated and overexpressed under administration of the Doxycycline (Doxy) in the drinking bottle of mice or fed with Ciproxine (Cipro) as a negative control of HoxA10 e...
ORGANISM(S): Mus musculus 
2010-08-21 | E-MEXP-2877 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse leukemia cells induced by HoxA10 forced expression - experiment 1
The Rosa-rtTAnls/tetO-HoxA10 mouse model is a Tetracycline-On (tetO) system in which the expression level of HoxA10 can be tightly regulated and overexpressed under administration of the Doxycycline (Doxy) in the drinking bottle of mice or fed with Ciproxine (Cipro) as a negative control of HoxA10 e...
ORGANISM(S): Mus musculus 
2010-08-18 | E-MEXP-2876 | biostudies-arrayexpress
GenomicsThe ability of PML/RARα to initiate leukemia is associated with markedly increased proliferation of promyelocytes despite minor changes in the transcriptome and epigenome.
Acute Promyelocytic Leukemia is characterized by the accumulation in the blood and bone marrow of promyelocytes. The PML/RARα fusion protein is identified as the primary abnormality implicated in the pathology, and is believed to prevent transcription of genes necessary for normal myeloid developmen...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-54038 | biostudies-arrayexpress
GenomicsGermline alterations of acute myeloid leukemia
Germline variants may increase the risk of cancer. A systematic analysis was conducted of a consecutive series of primary and secondary adult acute myeloid leukemia (AML) patients. Exome sequencing was performed on leukemic blasts (somatic) and a skin biopsy (germline) followed by analysis on 35 acu...
EGAS00001002760 | EGA
TranscriptomicsGenotyping analysis of AML samples at diagnosis and relapse after Hematopoietic Stem Cell Transplantation (HSCT)
Genotype profiling of Acute Myeloid Leukemia samples. This dataset includes patients with diagnosis of de novo or secondary AML who experienced non-HLA loss disease relapse after allo-HCT, and for whom paired pre- and post-transplant viable leukemic samples were available.
ORGANISM(S): Homo sapiens 
2019-01-30 | E-MTAB-7631 | biostudies-arrayexpress
TranscriptomicsIntegrated analysis of MLL-AF9 AML patients and model leukemias highlights RET and other novel therapeutic targets [RNA-Seq_AML]
Next generation DNA sequencing of acute myeloid leukemia (AML) patient samples has revealed novel recurrent mutations while at the same time highlighting the genetic heterogeneity of the disease. These observations suggest that an extraordinarily large number of combinations of mutations can contrib...
ORGANISM(S): Homo sapiens 
2017-05-02 | E-GEOD-71686 | biostudies-arrayexpress
Sort   by:  
 Page size