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TranscriptomicsHT-project: Expression profiling after prolonged experimental febrile seizures suggests structural remodeling in the hippocampus
Febrile seizures are the most prevalent type of seizures among children up to 5 years of age (2-4% of Western-European children). Complex febrile seizures are associated with an increased risk to develop temporal lobe epilepsy. To investigate short- and long-term effects of experimental febrile seiz...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-66762 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brains following nicotine-induced seizures
Nicotine, acting through the neuronal nicotinic acetylcholine receptors (nAChR), can induce seizures in mice. We aimed to study brain transcriptional response to seizure and to identify genes whose expression is altered after nicotine-induced seizures. Whole brains of untreated mice were compared to...
ORGANISM(S): Mus musculus 
2008-04-09 | E-GEOD-6614 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hippocampi of rats that were injected with kainic acid at postnatal day (P) 20 to induce early-life seizures and then housed in an enriched environment until P30
Neuropsychiatric consequences of poorly controlled seizures that begin in childhood can be devastating. School failure or behavioral difficulty in a child with epilepsy is common and can become the focus of concern for families. Current antiepileptic drugs compound problems with their CNS side effe...
ORGANISM(S): Rattus norvegicus 
2007-09-14 | E-GEOD-1833 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse P15 hippocampus in kainate-induced seizures
Early childhood convulsions have been correlated with hippocampal neuron loss in patients with intractable temporal lobe epilepsy. Using a "two-hit" rat seizure model, we have shown that animals subjected to kainate (KA)- or hypoxia-induced seizures during early postnatal period showed no cell deat...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1831 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hippocampus treated with kainate to induce seizures - time series
Mesial temporal lobe epilepsy (MTLE) is the most common medically refractory epilepsy syndrome; kainic acid (KA) induced seizures have been studied as a MTLE model as limbic seizures produced by systemic injections of KA result in a distinctive pattern of neurodegeneration in the hippocampus that re...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1834 | biostudies-arrayexpress
TranscriptomicsChanges in the gene expression in the inferior colliculus of the sound stimulated rats both Wistar and the strain susceptible to audiogenic seizures WAR
Using microarray analyses and subsequent verification by RT-PCR, we studied the changes in gene expression in the inferior colliculus after an ictal event in one models of audiogenic epilepsy, Wistar audigenic rat (WAR). WAR is a genetically selected strain susceptible to audiogenic seizures that wa...
ORGANISM(S): Rattus norvegicus 
2015-12-31 | E-GEOD-74150 | biostudies-arrayexpress
TranscriptomicsNeurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 7 of 10)
Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite...
ORGANISM(S): Colinus virginianus 
2011-11-23 | E-GEOD-33935 | biostudies-arrayexpress
GenomicsChIP-seq experiment in J20 hAPP mice and Pilocarpine-treated mice using deltaFosB antibody against whole-hippocampal lysate
∆FosB epigenetically regulates target gene expression; however, whether ∆FosB targets the same genes when induced by recurrent seizures in different neurological conditions like Alzheimer's disease (AD) is unclear. We performed hippocampal ChIP-sequencing to identify ∆FosB target genes in APP mice, ...
ORGANISM(S): Mus musculus 
2020-04-16 | E-MTAB-8954 | biostudies-arrayexpress
ProteomicsAcetylation profiles in the metabolic process of glioma-associated seizures
We used label-free based mass spectrometry-based quantitative proteomics to quantify dynamic changes of protein acetylation between gliomas with seizure (CA1 group) and gliomas without seizure (CA2 group).We further classified acetylated proteins into groups according to cell component, molecular fu...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD027864 | Pride
Metabolic process Glioma-associated seizures Lysine acetylation 
TranscriptomicsRat model of MTLE: Animals with epilepsy vs animals without epilepsy (codelink)
Neither the molecular basis of the pathologic tendency of neuronal circuits to generate spontaneous seizures (epileptogenicity) nor anti-epileptogenic mechanisms that maintain a seizure-free state are well understood. Here, we performed transcriptomic analysis in the intrahippocampal kainate model o...
ORGANISM(S): Rattus norvegicus 
2011-02-13 | E-GEOD-27166 | biostudies-arrayexpress
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