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TranscriptomicsEstrogens and selective estrogen receptor modulators regulate gene and protein expression in the mesenteric arteries
Estrogen is a reproductive steroid hormone that has both beneficial and detrimental effects on the cardiovascular system. Selective estrogen receptor modulators (SERMs) exhibit partial estrogen agonist/antagonist activity in estrogen target tissues. Since we still have an incomplete picture of the ...
ORGANISM(S): Rattus norvegicus 
2011-07-06 | E-GEOD-23037 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer
In this study, we have utilized microarray analysis to directly compare a subset of structurally distinct, clinically relevant SERMs in the presence and absence of estradiol, using a high replicate number (10) to ensure detection of modestly regulated genes. Tested compounds included 4-hydroxytamoxi...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-35428 | biostudies-arrayexpress
TranscriptomicsEstrogen receptor prevents p53-dependent apoptosis in breast cancer
More than two thirds of breast cancers express the estrogen receptor (ER) and depend on estrogen for growth and survival. Therapies targeting ER function including aromatase inhibitors that block the production of estrogens and ER antagonists that alter ER transcriptional activity play a central rol...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-39870 | biostudies-arrayexpress
UnknownMeasuring selective estrogen receptor modulator (SERM)-membrane interactions with second harmonic generation.
Not available
S-EPMC4004268 | biostudies-literature
UnknownTransactivation Function-1-Mediated Partial Agonist Activity of Selective Estrogen Receptor Modulator Requires Homo-Dimerization of the Estrogen Receptor α Ligand Binding Domain.
Not available
S-EPMC6695978 | biostudies-literature
TranscriptomicsEffect of estrogen and selective estrogen receptor modulators on a mouse model of fallopian tube epithelia, an ovarian cancer precursor
The fallopian tube epithelium is one of the potential sources of high-grade serous ovarian cancer (HGSC). The use of estrogen only hormone replacement therapy increases ovarian cancer risk. Despite estrogenâ??s influence in OVCA, selective estrogen receptor modulators (SERMs) typically demonstrate o...
ORGANISM(S): Mus musculus 
2016-02-08 | E-GEOD-67207 | biostudies-arrayexpress
UnknownSelective estrogen receptor modulator with estrogen does not affect the proliferation and apoptosis of uterine leiomyoma cells.
Not available
S-EPMC8798564 | biostudies-literature
TranscriptomicsNovel selective regulation of hematopoietic progenitor self-renewal, survival and proliferation by estrogens has therapeutic potential in myeloproliferative neoplasms
Estrogens are potential regulators of the hematopoietic stem cell (HSC) niche and have effects on mature hematopoietic cells; however, whether estrogen signaling directly regulates normal and malignant HSC remains unclear. We demonstrate differential expression and specific roles of estrogen recepto...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-62621 | biostudies-arrayexpress
UnknownThe effects of 17β-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis.
Not available
S-EPMC3249832 | biostudies-literature
UnknownSelective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells.
Not available
S-EPMC2814347 | biostudies-literature
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