solvent-induced proteome profiling (spp)

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Drug Delivery, Disposition and Dynamics; Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University (Parkville campus) (1)

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Validation of Solvent Proteome Profiling for Antimalarial Drug Target Deconvolution

Malaria remains a global health threat, with rising drug resistance accelerating the urgent need for new therapeutics. Target elucidation is a critical step in antimalarial drug discovery, enabling a deeper understanding of the molecular mechanisms of action of both existing and novel compounds. Thi...

ORGANISM(S): Plasmodium falciparum (isolate 3D7)

2025-11-25 | PXD071156 | Pride

Validation of solvent proteome profiling for antimalarial drug target deconvolution.

Not available

S-EPMC12688689 | biostudies-literature

Assessing target engagment using proteome-wide solvent shift assays

Recent advances in mass spectrometry (MS) have enabled quantitative proteomics to become a powerful tool in the field of drug discovery, especially when applied toward proteome-wide target engagement studies. Similar to temperature gradients, increasing concentrations of organic solvents stimulate u...

ORGANISM(S): Homo sapiens (Human)

2022-02-17 | PXD026297 | Pride

Target enagagement

Assessing target engagement using proteome-wide solvent shift assays.