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TranscriptomicsTranscription profiling of mouse knock in mutant model for spinocerebellar ataxia type 1 and type 7 - symptomatic Sca1154Q/2Q and Sca7266Q/5Q cerebellum
Comparative analysis of cerebellar gene expression changes occurring in Sca1154Q/2Q and Sca7266Q/5Q knock-in mice; Polyglutamine diseases are inherited neurodegenerative disorders caused by expansion of CAG repeats encoding a glutamine tract in the disease-causing proteins. There are nine disorders...
ORGANISM(S): Mus musculus 
2009-01-09 | E-GEOD-9914 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ataxin-null (Atxn-null) vs. wild type mice to investigate spinocerebellar ataxia type 1 (SCA1)
Ataxin 1 (Atxn1) is a protein of unknown function associated with cerebellar neurodegeneration in spinocerebellar ataxia type 1 (SCA1). SCA1 is caused by an expanded polyglutamine within Atxn1 by gain-of-function mechanisms. Lack of Atxn1 in mice triggers motor deficits in the absence of neurodegene...
ORGANISM(S): Mus musculus 
2006-12-01 | E-MEXP-886 | biostudies-arrayexpress
TranscriptomicsCapicua-dependent transcriptional changes in adult mouse cerebellum
Analysis of cerebella from Capicua (Cic) mutant mice and wild-type controls at 28 days of age (P28). Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). The transcriptional repressor Cic binds directly to Atxn1...
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-32051 | biostudies-arrayexpress
TranscriptomicsTranscriptional changes occurring in end-stage human SCA1 cerebellum.
RNA-Seq was performed in post-mortem SCA1 cerebellum at the end stage of the disease and an age/sex-matched control tissue from a healthy individual.
ORGANISM(S): Homo sapiens 
2020-02-18 | E-MTAB-7714 | biostudies-arrayexpress
UnknownNeurochemical Differences in Spinocerebellar Ataxia Type 14 and 1.
Not available
S-EPMC8004522 | biostudies-literature
GenomicsTranscriptomic approach reveals splicing dysregulation in spinocerebellar ataxia type 1
Transcriptomic approach reveals splicing dysregulation in spinocerebellar ataxia type 1
PRJNA971864 | ENA
UnknownAstroglia contribute to the pathogenesis of spinocerebellar ataxia Type 1 (SCA1) in a biphasic, stage-of-disease specific manner.
Not available
S-EPMC8049102 | biostudies-literature
TranscriptomicsRNA-seq of human mesenchymal stem cells inducibly overexpressing human ataxin-1(Q82)
A protein aggregation model of human ataxin-1(Q82) was generated in human mesenchymal cells using the Sleeping Beauty transposon system. These cells inducibly express the pathogenic protein that causes SCA1 disease. Here, we describe the transcriptional changes occurring in cells which contain diffe...
ORGANISM(S): Homo sapiens 
2020-02-18 | E-MTAB-7713 | biostudies-arrayexpress
UnknownSex Differences in a Novel Mouse Model of Spinocerebellar Ataxia Type 1 (SCA1).
Not available
S-EPMC11942590 | biostudies-literature
TranscriptomicsTranscription profiling of mouse model for spinocerebellar ataxia 1 vs, wild type littermates sampled at 4 and 11 weeks
A number of human neurodegenerative diseases result from the expansion of a glutamine repeat within the disease-causing protein. Spinocerebellar ataxia type1 is one such disease, caused by expansion of a polyglutamine tract in the novel protein ataxin-1. To faithfully model SCA1 in the mouse, we gen...
ORGANISM(S): Mus musculus 
2007-07-07 | E-GEOD-2867 | biostudies-arrayexpress
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