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TranscriptomicsPhenotype Enhancement Screen of a Regulatory spx Mutant Unveils a Role for the ytpQ Gene in the Control of Iron Homeostasis.
Spx is a global regulator of genes that are induced by disulfide stress in Bacillus subtilis. Most of the Spx-regulated genes (SRGs) are of unknown function, but many encode products conserved in low %GC Gram positive bacteria. Using a gene-disruption library of B. subtilis genomic mutations, the SR...
ORGANISM(S): Bacillus subtilis 
2011-10-24 | E-GEOD-28872 | biostudies-arrayexpress
TranscriptomicsThe regulon of the pleiotropic transcription factor Spx in Bacillus subtilis
The transcriptional regulator Spx plays a key role in maintaining the redox homeostasis of Bacillus subtilis cells exposed to disulfide stress. Defects in Spx were previously shown to lead to differential expression of numerous genes but direct and indirect regulatory effects could not be distinguis...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2012-09-06 | E-GEOD-35097 | biostudies-arrayexpress
TranscriptomicsStreptococcus mutans UA159 vs. spx mutant strains
Transcriptional profiling to investigate the regulatory roles of SpxA and SpxB of S. mutans. RNA was extracted from four replicate samples of each strain of interest (spxA mutant, spxB mutant, spxAB double-mutant, UA159 wild type) and labeled with Cy3. For each replicate, labeled RNA was hybridized...
ORGANISM(S): Streptococcus mutans 
2010-05-16 | E-GEOD-19656 | biostudies-arrayexpress
TranscriptomicsSigma(M) regulated genes under antibiotic stress (vancomycin)
Abstract of associated manuscript: The Bacillus subtilis extracytoplasmic function (ECF) sigma(M) factor is activated by cell envelope stress elicited by antibiotics, and by acid, heat, ethanol and superoxide stresses. Here, we have used several complementary approaches to identify genes controlled ...
ORGANISM(S): Bacillus subtilis 
2010-05-15 | E-GEOD-13820 | biostudies-arrayexpress
TranscriptomicsComparison of the transcription profile of B. subtilis clpX strain with B. subtilis clpX spx strain, reporting on Spx activity
In B. subtilis the unusual transcription factor Spx controls the thiol stress response regulon (Nakano et al 2003 PNAS 100:13603; Rochat et a. 2012 NAR 40:9751). Under normal growth conditions Spx is constantly degraded by the AAA+ protease complex ClpXP (Nakano et al 2001 MolMi 42:383). Comparing a...
ORGANISM(S): Bacillus subtilis 
2014-09-01 | GSE50102 | GEO
TranscriptomicsComparison of the transcription profile of B. subtilis clpX strain with B. subtilis clpX spx strain, reporting on Spx activity
In B. subtilis the unusual transcription factor Spx controls the thiol stress response regulon (Nakano et al 2003 PNAS 100:13603; Rochat et a. 2012 NAR 40:9751). Under normal growth conditions Spx is constantly degraded by the AAA+ protease complex ClpXP (Nakano et al 2001 MolMi 42:383). Comparing a...
ORGANISM(S): Bacillus subtilis 
2014-09-01 | E-GEOD-50102 | biostudies-arrayexpress
GenomicsThe regulon of the pleiotropic transcription factor Spx in Bacillus subtilis
The transcriptional regulator Spx plays a key role in maintaining the redox homeostasis of Bacillus subtilis cells exposed to disulfide stress. Defects in Spx were previously shown to lead to differential expression of numerous genes but direct and indirect regulatory effects could not be distinguis...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2012-09-06 | GSE35097 | GEO
UnknownIdentification of Novel Spx Regulatory Pathways in Bacillus subtilis Uncovers a Close Relationship between the CtsR and Spx Regulons.
Not available
S-EPMC6560146 | biostudies-literature
UnknownmiR827 orchestrates the regulation of SPX-MFS1 and SPX-MFS5 with the assistance of lncRNA767 to enhance phosphate starvation tolerance and maize development.
Not available
S-EPMC11606416 | biostudies-literature
TranscriptomicsPhenotype Enhancement Screen of a Regulatory spx Mutant Unveils a Role for the ytpQ Gene in the Control of Iron Homeostasis.
Spx is a global regulator of genes that are induced by disulfide stress in Bacillus subtilis. Most of the Spx-regulated genes (SRGs) are of unknown function, but many encode products conserved in low %GC Gram positive bacteria. Using a gene-disruption library of B. subtilis genomic mutations, the SR...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 Bacillus subtilis 
2011-10-25 | GSE28872 | GEO
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