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ProteomicsProfiling N-myristoyltransferase activity and inhibition in breast cancer cells (MD-MB-231) using Sortase-A labelling
We report a novel application for Sortase A (SrtA), labeling N-terminal Gly proteins across the proteome at endogenous levels. We combined SrtA labeling of whole-cell lysates with a potent and selective NMT inhibitor, delivering a method capable of quantifying changes in cellular NMT activity in mul...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD010634 | Pride
Sortase a  srta  n-myristoylation  nmt 
GenomicsRNA-Seq expression profiling of srta mutant and WT strains of Chlamydomonas reinhardtii
RNA-Seq expression profiling of srta mutant and WT strains of Chlamydomonas reinhardtii
PRJNA529641 | ENA
TranscriptomicsRNA-Seq expression profiling of srta mutant and WT strains of Chlamydomonas reinhardtii
Two strains of the green alga, Chlamydomonas reinhardtii, were selected for high expression of transgenes. These strains, called UVM4 and UVM11, were found to both have unique mutations in the SRTA gene (Cre10.g462200). In this study, the basal transcriptome of these two strains was compared to that...
ORGANISM(S): Chlamydomonas reinhardtii 
2020-10-23 | GSE128981 | GEO
UnknownRole of SrtA in Pathogenicity of Staphylococcus lugdunensis.
Not available
S-EPMC7763024 | biostudies-literature
UnknownInterrogation of Bacillus anthracis SrtA active site loop forming open/close lid conformations through extensive MD simulations for understanding binding selectivity of SrtA inhibitors.
Not available
S-EPMC8241892 | biostudies-literature
UnknownDirected evolution provides insight into conformational substrate sampling by SrtA.
Not available
S-EPMC5578623 | biostudies-literature
UnknownUncovering Roles of Streptococcus gordonii SrtA-Processed Proteins in the Biofilm Lifestyle.
Not available
S-EPMC7950405 | biostudies-literature
UnknownImproved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency.
Not available
S-EPMC4989145 | biostudies-literature
MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
UnknownStructural differences between the Streptococcus agalactiae housekeeping and pilus-specific sortases: SrtA and SrtC1.
Not available
S-EPMC3166054 | biostudies-literature
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