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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
GenomicsAltered Subcellular Localization of Transcription Factor TEAD4 Regulates First Mammalian Cell Lineage Commitment
In the preimplantation mouse embryo TEAD4 is critical to establishing the trophectoderm (TE)-specific transcriptional program and segregating TE from the inner cell mass (ICM). However, TEAD4 is expressed both in the TE and the ICM. Thus, differential function of TEAD4 rather than expression itself ...
ORGANISM(S): Mus musculus 
2012-04-18 | E-GEOD-37350 | biostudies-arrayexpress
TranscriptomicsRole of Aldoketoreductases and Other Doxorubicin Pharmacokinetic Genes in Doxorubicin Resistance, DNA binding, and Subcellular Localization
Objective: To assess the role of aldoketoreductases and other doxorubicin pharmacokinetic or pharmacogenomic genes in doxorubicin cytotoxicity, resistance, DNA binding activity, and subcellular localization, Methods: We conducted a whole genome microarray study to identify differences in betwee...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-27254 | biostudies-arrayexpress
ProteomicsSubCellBarcode: Scalable proteome-wide mapping of protein localization and relocalization
We have devised a simple and robust LC-MS/MS compatible protocol for subcellular protein localization studies. Here, we combine it with in depth proteome profiling and utilize the resulting dataset to predict the subcellular localization of more than 12000 proteins in 5 human cancer cell lines. The ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-17 | MSV000086899 | MassIVE
ProteomicsSimultaneous proteome localization and turnover analysis reveals spatiotemporal coordinations of unfolded protein response
The functionality of proteins is dependent on their spatial and temporal distributions, neither of which is directly measured by static protein abundance. Here we report a mass spectrometry-based proteomics workflow and data analysis pipeline, named Simultaneous Proteome Localization and Turnover (...
ORGANISM(S): Homo Sapiens (human) 
2022-12-31 | PXD038054 | JPOST Repository
GenomicsSubcellular mRNA localization patterns across tissues resolved with spatial transcriptomics
Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics
PRJNA1449500 | ENA
TranscriptomicsRNA Subcellular CAGE Localization from ENCODE/RIKEN
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Piero Carninci mailto:carninci@riken.jp). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). This track show...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-34448 | biostudies-arrayexpress
GenomicsAtlas of subcellular RNA localization in human embryonic stem cells and its flow during differentiation
Atlas of subcellular RNA localization in human embryonic stem cells and its flow during differentiation
PRJNA850166 | ENA
ProteomicsSubcellular Localization Shapes the Fate of RNA Polymerase III-2
RNA Pol III plays a vital role in transcription and as a viral-DNA sensor, but how it is assembled and distributed within cells remain poorly understood. Here, we show that Pol III is assembled with chaperones in the cytoplasm and forms transcription-dependent protein clusters upon transport into th...
ORGANISM(S): Mus Musculus 
PXD042522 |
GenomicsSubcellular RNA localization during Drosophila embryonic neurogenesis [fractionation-Seq]
Subcellular RNA localization during Drosophila embryonic neurogenesis [fractionation-Seq]
PRJNA415601 | ENA
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