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ProteomicsSynthetic polyclonal-derived CDR peptides as innovative strategy in glaucoma therapy
The pathogenesis of glaucoma is strongly associated with the occurrence of autoimmune-mediated loss of retinal ganglion cells (RGCs) and recently it was proven that specific antibody-derived signature peptides are significantly differentially expressed in sera of primary open angle glaucoma patients...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2019-08-15 | PXD014718 | Pride
Glaucoma  autoimmunity  synthetic cdr peptides  neuroprotection  htra2  sus scrofa domesticus 
UnknownSynthetic Polyclonal-Derived CDR Peptides as an Innovative Strategy in Glaucoma Therapy.
Not available
S-EPMC6723090 | biostudies-literature
ProteomicsRegulation of the HTRA2 protease activity by PDZ domain-binding peptide ligands and the influence on HTRA2-specific protein interaction networks in retinal tissues
For the identification of HTRA2-specific protein interaction partners in retinal tissues of the house swine (Sus scrofa), we performed co-immunoprecipitation experiments with recombinant 6His-tag HTRA2 followed by quantitative LC-MS-based proteomics (see Fig. 2A and File S1). In brief, 2 µg recombin...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2021-10-11 | PXD024442 | Pride
Htra2  neuroprotection  retina  interaction partners  co-immunoprecipitation  mass spectrometry 
ProteomicsHDX-MS implicates dynamic CD20 antigen binding to two discontinuous CDR regions in the NCD1.2 monoclonal antibody
A comparative canine-human therapeutics model is being developed in B-cell lymphoma through the generation of a hybridoma cell that produces a murine monoclonal antibody specific for canine CD20. The hybridoma cell produces two light chains, light chain-3 and light chain-7. However, the contribution...
ORGANISM(S): Canis lupus x Canis lupus familiaris 
2021-09-09 | PXD018550 | Pride
Human Comparative medicine Lymphoma Monoclonal antibody Hdx Adept Phage display Cd20 
ProteomicsHydrogen Deuterium Exchange Mass Spectrometry implicates dynamic CD20 antigen binding to two discontinuous CDR regions in the NCD1.2 monoclonal antibody
A comparative canine-human therapeutics model is being developed in B-cell lymphoma through the generation of a hybridoma cell that produces a murine monoclonal antibody specific for canine CD20. The hybridoma cell produces two light chains, light chain-3 and light chain-7. However, the contribution...
ORGANISM(S): Canis lupus x Canis lupus familiaris 
2021-09-09 | PXD018510 | Pride
Human Comparative medicine Lymphoma Monoclonal antibody Hdx Adept Phage display Cd20 Lc-ms/ms 
UnknownCerebrospinal Aβ11-x and 17-x levels as indicators of mild cognitive impairment and patients' stratification in Alzheimer's disease.
Not available
S-EPMC3731790 | biostudies-literature
Unknownβ-Actin-binding complementarity-determining region 2 of variable heavy chain from monoclonal antibody C7 induces apoptosis in several human tumor cells and is protective against metastatic melanoma.
Not available
S-EPMC3340220 | biostudies-literature
UnknownPhage Display Analysis of Monoclonal Antibody Binding to Anthrax Toxin Lethal Factor
Not available
S-EPMC5535168 | biostudies-literature
UnknownIdentification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity.
Not available
S-EPMC10215015 | biostudies-literature
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