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ProteomicsTargeted dephosphorylation of TFEB promotes its nuclear translocation
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localised to the cytoplasm. Stressor-mediated reduction of TFEB phosphorylation prom...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053311 | Pride
Adphosphotase Dephosphorylation Bdpic Ppp2ca Tfeb Phostac 
ProteomicsAn affinity-directed phosphatase (AdPhosphatase) system for targeted protein dephosphorylation
Reversible protein phosphorylation, catalysed by protein kinases and phosphatases, is a fundamental process that controls protein function and intracellular signalling. Failure of phospho-control accounts for many human diseases. While a kinase phosphorylates multiple substrates, a substrate is o...
ORGANISM(S): Homo sapiens (Human) 
2023-02-01 | PXD039200 | Pride
Affinity-directed phosphatase  adphosphatase  targeted dephosphorylation  ppp1ca ppp2ca  nanobody  ulk1  fam83d 
ProteomicsTargeted dephosphorylation of TFEB promotes its nuclear translocation
Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localised to the cytoplasm. Stressor-mediated reduction of TFEB phosphorylation prom...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD053308 | Pride
Bdpic Ppp2ca Tfeb Adphosphatase Phostac 
UnknownTargeted dephosphorylation of TFEB promotes its nuclear translocation.
Not available
S-EPMC11284556 | biostudies-literature
ProteomicsDIA-MS Detect the Dephosphorylation of Tau by Phosphorylation Targeting Chimera (PhosTAC)
Microtubule-associated protein tau is essential for microtubule assembly and stabilization. Hyperphosphorylation of the microtubule-associated protein tau plays an important pathological role in the development of Alzheimer’s disease and other tauopathies, one of the greatest unmet demands in the cl...
ORGANISM(S): Homo sapiens (Human) 
2023-03-16 | PXD037459 | Pride
Dephosphorylation Dia-ms Tau Phostac Phosphoproteomics 
ProteomicsAMPK activation promotes transcriptional activation of TFEB through its dephosphorylation
Transcription Factor EB (TFEB) is a critical regulator of lysosomal biogenesis, autophagy and energy homeostasis through regulating expression of genes belonging to the Coordinated Lysosomal Expression and Regulation network. Recently, AMP-activated protein kinase (AMPK) was reported to phosphorylat...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-11 | PXD055410 | Pride
Bay-3827  coordinated lysosomal expression and regulation  mk-8722  reversible phosphorylation  mtor  tfe3 
UnknownTargeted dephosphorylation of SMAD3 as an approach to impede TGF-β signaling.
Not available
S-EPMC11298613 | biostudies-literature
ProteomicsDIA-MS Detect the Targeted EGFR Dephosphorylation by Phosphorylation Targeting Chimera (PhosTAC)
Epidermal growth factor receptor (EGFR) is an important receptor tyrosine kinase protein. Activated EGFR promotes downstream signal transductions through phosphorylation, and its phosphorylation has been implicated in pathologies including many types of cancers. Previously, our lab has developed the...
ORGANISM(S): Homo sapiens (Human) 
2024-04-02 | PXD038022 | Pride
Phosphoproteomics Dia-ms Phostac Egfr Kinase 
GenomicsTargeted nanopore resequencing and methylation analysis of LINE-1 retrotransposons
We used the nanopore Cas9 targeted sequencing (nCATS) strategy to specifically sequence 125 L1HS-containing loci in parallel and measure their DNA methylation levels using nanopore long-read sequencing. Each targeted locus is sequenced at high coverage (~45X) with unambiguously mapped reads spanning...
ORGANISM(S): Homo sapiens 
2023-09-22 | E-MTAB-12247 | biostudies-arrayexpress
UnknownA novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies.
Not available
S-EPMC8280143 | biostudies-literature
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