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ProteomicsTFIP11 competes with the Bloom syndrome helicase for binding to stalled replication forks to preserve genome stability
Replication fork reversal is a key protective mechanism against replication stress in higher eukaryotic cells and occurs via a series of coordinated enzymatic reactions. The Bloom syndrome gene product, BLM, is a member of the highly conserved RecQ helicase family and has been implicated in this pro...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042222 | Pride
Bloom syndrome helicase  replication stress  replication fork reversal  genome instability  tfip11 
GenomicsiCLIP of HeLa cells with anti-TFIP11 antibody
iCLIP of HeLa cells with anti-TFIP11 antibody
PRJNA665725 | ENA
OtheriCLIP of HeLa cells with anti-TFIP11 antibody
iCLIP of HeLa cells with anti-TFIP11 antibody to investigate RNA binding locations of TFIP11 as part of a larger study on the function of TFIP11.
ORGANISM(S): Homo sapiens 
2021-09-22 | GSE158589 | GEO
UnknownTFIP11 interacts with mDEAH9, an RNA helicase involved in spliceosome disassembly.
Not available
S-EPMC2629433 | biostudies-literature
UnknownTFIP11 promotes replication fork reversal to preserve genome stability.
Not available
S-EPMC10858868 | biostudies-literature
UnknownTFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization.
Not available
S-EPMC2605624 | biostudies-literature
UnknownDHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity.
Not available
S-EPMC8599867 | biostudies-literature
GenomicsRole of TFIP11 in U6 snRNA modification and splicing efficiency
Role of TFIP11 in U6 snRNA modification and splicing efficiency
PRJNA657749 | ENA
TranscriptomicsRNA-Seq of HeLa cells treated with siTFIP11
RNA-Seq of HeLa cells treated with siTFIP11 or control siRNA to investigate the effect of TFIP11 knockdown on mRNA as part of a larger study on the function of TFIP11.
ORGANISM(S): Homo sapiens 
2021-09-22 | GSE156388 | GEO
OtherRiboMethSeq of HCT116 cells treated with siTFIP11 or siDHX15
RiboMethSeq of HCT116 cells treated with siTFIP11 or siDHX15 to investigate the effect of TFIP11 or DHX15 knockdown on RNA methylation as part of a larger study on the function of TFIP11.
ORGANISM(S): Homo sapiens 
2021-09-22 | GSE163369 | GEO
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