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Disease

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Hepatocellular carcinoma-non tumorous region (1)
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Pre-tumoral lesion in a mouse model of human adamantinomatous craniopharyngioma (ACP) (1)
Follicular thyroid carcinoma (1)
Basal cell carcinoma, Gorlin-Goltz syndrome (1)
Crohn's disease (1)
Rheumatoid arthritis (1)
Invasive lobular carcinoma (1)
Leukemia (1)
Melanoma (1)
Giant Cell Glioblastoma (1)

Technology Type

Mass Spectrometry (218)
Shotgun proteomics (112)
Bottom-up proteomics (38)
Mass spectrometry (25)
Illumina HiSeq 2000 (7)
Fluorescence intensity (6)
Fluorescence imaging (5)
Mass spectrometry assay (4)
ILLUMINA, Illumina HiSeq 2000 (3)
Illumina HiSeq 2500 (3)
Illumina HiSeq 2500, ILLUMINA (2)
ILLUMINA, Illumina HiSeq 2500 (2)
Illumina MiSeq (2)
NMR spectroscopy (2)
ESI (2)
HiSeq X Ten, Illumina HiSeq 4000, Illumina HiSeq 2500, ILLUMINA (1)
Codelink Human Whole Genome Bioarray (1)
Illumina HiSeq 2500, Illumina HiSeq 2000 (ILLUMINA), Illumina HiSeq 2000, Illumina (1)
ABI_SOLID, Illumina HiSeq 2000, Illumina 450K, AB 5500xl Genetic Analyzer, AB 5500 Genetic Analyzer, ILLUMINA (1)
Illumina HiSeq 4000, Illumina HiSeq 2500, ILLUMINA (1)
CYTOSCANHD, ILLUMINA, HUMANOMNI1QUAD, HUMANOMNIEXPRESS, Affymetrix HG_U133_+2, Illumina HiSeq 2000 (1)
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Affymetrix SNP 6.0, Illumina Genome Analyzer IIx (1)
Illumina HiSeq 2000, ILLUMINA (1)
Microwestern (1)
Other (1)
EI (1)

Instrument Platform

Illumina NovaSeq 6000 (88)
Illumina HiSeq 4000 (55)
NextSeq 500 (52)
Illumina HiSeq 2500 (50)
Illumina HiSeq 2000 (34)
Illumina Genome Analyzer IIx (7)
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418 [Affymetrix] (2)
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Publication Date

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2009 (162)
2017 (161)
2007 (116)
2006 (44)
2005 (33)
2004 (18)
2003 (5)

UNIPROT ID/AC

P01137 (9)
Q13485 (5)
P36897 (5)
Q15796 (4)
P37173 (4)
Q14609 (2)
Q8NER5 (2)
P04202 (2)
Q49IL8 (1)
B5MCZ3 (1)
P06238 (1)
P20961 (1)
Q71SA3 (1)
P17246 (1)
P29598 (1)
Q01177 (1)
Q15116 (1)
P16410 (1)
P49767 (1)
O75636 (1)
O00602 (1)
Q96A83 (1)
Q96CG8 (1)
Q2UY09 (1)
Q8IZC6 (1)
Q9BXS0 (1)
Q17RW2 (1)
Q86Y22 (1)
Q8NFW1 (1)
Q9Y215 (1)

ENSEMBL ID

ENSMUSG00000031170 (1)
ENSMUSG00000010064 (1)
ENSMUSG00000024036 (1)
ENSMUSG00000020261 (1)
ENSMUSG00000031156 (1)
ENSMUSG00000037434 (1)
ENSMUSG00000025082 (1)
ENSMUSG00000070436 (1)
ENSMUSG00000037936 (1)
ENSMUSG00000015533 (1)
ENSMUSG00000042284 (1)
ENSMUSG00000041559 (1)
ENSMUSG00000026938 (1)
ENSMUSG00000021553 (1)
ENSMUSG00000004415 (1)
ENSMUSG00000054196 (1)
ENSMUSG00000068794 (1)
ENSMUSG00000045672 (1)
ENSMUSG00000058897 (1)
ENSMUSG00000028197 (1)
ENSMUSG00000063564 (1)
ENSMUSG00000079022 (1)
ENSMUSG00000057606 (1)
ENSMUSG00000016356 (1)
ENSMUSG00000046959 (1)
ENSMUSG00000024354 (1)
ENSMUSG00000026141 (1)
ENSMUSG00000001435 (1)
ENSMUSG00000025064 (1)
ENSMUSG00000040690 (1)

CHEBI ID

CHEBI:28728 (4)
CHEBI:15996 (2)
CHEBI:17552 (2)
CHEBI:15493 (1)
CHEBI:35222 (1)
CHEBI:114785 (1)
CHEBI:28092 (1)
CHEBI:2070 (1)
CHEBI:21285 (1)
CHEBI:18402 (1)
CHEBI:16466 (1)
CHEBI:28508 (1)
CHEBI:28095 (1)
CHEBI:15494 (1)
CHEBI:16577 (1)
CHEBI:57495 (1)
CHEBI:16934 (1)
CHEBI:28189 (1)
CHEBI:1949 (1)
CHEBI:58321 (1)
CHEBI:9907 (1)
CHEBI:28922 (1)
CHEBI:28852 (1)
CHEBI:34939 (1)
CHEBI:27696 (1)
CHEBI:27555 (1)
CHEBI:15546 (1)
CHEBI:28099 (1)
CHEBI:27624 (1)
CHEBI:16325 (1)

Metabolite Name

Thymine (9)
Creatinine (9)
L-Lysine (8)
Creatine (8)
Uracil (7)
Choline (7)
Thiamine (6)
L-Aspartic acid (6)
Kynurenic acid (6)
L-Histidine (6)
Indole (6)
L-Proline (6)
Ectoine (6)
Adenosine (6)
Guanine (6)
N-Acetyl-L-alanine (6)
L-Tryptophan (6)
Adenine (6)
L-Valine (6)
L-Methionine (6)
L-Tyrosine (6)
L-Phenylalanine (6)
Hypoxanthine (6)
Betaine (5)
Pyroglutamic acid (5)
N6-Acetyl-L-lysine (5)
Argininosuccinic acid (5)
4-Pyridoxic acid (5)
Acetylcholine (5)
Taurine (5)

First Public Date

2014 (426)
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2024 (359)
2023 (255)
2022 (251)
2021 (199)
2020 (185)
2019 (168)
2017 (120)
2018 (111)
2015 (78)
2016 (51)
2013 (33)

Modelling Approach

Ordinary differential equation model (22)
Logical model (4)
Fuzzy logic model (1)
Boolean model (1)
Differential equation model (1)

Study status

Completed (5)
Recruiting (2)
Withdrawn (1)
Not provided (1)

Lab affiliation

National Health Research Institutes, Taiwan (3)
University of Vigo (3)
Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (2)
Guangdong Pharmaceutical University (2)
Head Proteomics Group, Leiden University Medical Center, Center for Proteomics and Metabolomics, PO Box 9600, Postal zone P1-Q, 2300 RC Leiden, The Netherlands (2)
SIMM (2)
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, Guangdong, P.R. China. (2)
University of Liverpool (2)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (2)
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal - ICVS/3B’s Associate Lab, PT Government Associated Lab, Portugal (1)
1 IBMC-Institute for Molecular and Cell Biology, i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal 2 ICBAS-School of Medicine and Biomedical Sciences, Universidade do Porto, Porto, Portugal (1)
2Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Madison, WI 53705, USA (1)
Advanced Mass Spectrometry Center, Research Core Facility, Frontiers Scienc Center for Disease-Related Molecular Network, West China Hospital (1)
Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of USC, Los Angeles, CA, 90033, USA (1)
Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER) - University of Seville (1)
Animal Cell Technology Unit, iBET - Instituto de Biologia Experimental e Tecnológica (1)
Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA (1)
Assistant Member, Immunology Department St. Jude Children's Research Hospital Memphis, TN USA (1)
Augusta University (1)
BK21 Plus KNU Multi-Omics-based Creative Drug Research Team, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Republic of Korea (1)
Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS) School of Life Sciences Technical University Munich (TUM) Gregor-Mendel-Straße 4 85354 Freising GERMANY Bavarian Center for Biomolecular Mass Spectrometry Technische Universität München Gregor-Mendel-Straße 4 85354 Freising DEUTSCHLAND / GERMANY (1)
Bertis R&D Division, Bertis Inc., Republic of Korea (1)
Biochemistry, University of Turku, Turku, Finland (1)
Biozentrum, University of Basel, Klinglebergstrasse 50/70, CH-4056 Basel (1)
Bone and Cartilage Research Unit, Arthropôle Liège, University of Liège, Liège, Belgium (1)
Bram Snijders Head of Mass Spectrometry Proteomics Platform The Francis Crick Institute 1 Midland Road London NW1 1AT T: +442037962038 E: bram.snijders@crick.ac.uk W: https://crims.crick.ac.uk/ (1)
CNRS UMS3444-Protein Science Facility (1)
COld Spring Harbor Laboratory (1)
CRCM (Marseille Protéomique), Inserm U1068, Institut Paoli-Calmettes, Aix-Marseille Université, UM105, CNRS UMR7258, Marseille (1)
CRUK - Scotland Institute - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)

Keyword

Capecitabine (2)
TGF- beta activated (1)
Trabedersen (1)
Advanced tumor (1)
Antisense (1)
Transforming Growth Factor beta 2 (1)
Stage I salivary gland cancer (1)
Stage II salivary gland cancer (1)
Metastatic squamous neck cancer with occult primary squamous cell carcinoma (1)
High-grade salivary gland mucoepidermoid carcinoma (1)
Salivary gland adenocarcinoma (1)
Salivary gland adenoid cystic carcinoma (1)
Salivary gland anaplastic carcinoma (1)
Salivary gland malignant mixed cell type tumor (1)
Salivary gland poorly differentiated carcinoma (1)
Salivary gland squamous cell carcinoma (1)
Low-grade salivary gland mucoepidermoid carcinoma (1)
Salivary gland acinic cell tumor (1)
Stage III salivary gland cancer (1)
Stage IV salivary gland cancer (1)
Recurrent salivary gland cancer (1)
Male breast cancer (1)
Stage III squamous cell carcinoma of the hypopharynx (1)
Stage IV squamous cell carcinoma of the hypopharynx (1)
Recurrent squamous cell carcinoma of the hypopharynx (1)
Stage III squamous cell carcinoma of the larynx (1)
Stage III verrucous carcinoma of the larynx (1)
Stage IV squamous cell carcinoma of the larynx (1)
Stage IV verrucous carcinoma of the larynx (1)
Recurrent squamous cell carcinoma of the larynx (1)

IsPrivate

False (31)

Model Flag

Non Kinetic (2)

Submitter Keywords

Immuno-oncology (6)
Oncology (1)
Not Peer Reviewed (1)

Classification

helminths (4)

Modification

-17.026549 (1)
15.994915 (1)
42.010565 (1)
6.020129 (1)

Study type

Transcription profiling by array (2159)
RNA-seq of coding RNA (393)
ChIP-seq (183)
Comparative genomic hybridization by array (67)
Methylation profiling by array (56)
Unknown experiment type (55)
RNA-seq of coding RNA from single cells (54)
Other (38)
RNA-seq of non coding RNA (37)
Cell line - High-throughput sequencing (24)
ChIP-chip by tiling array (21)
Transcription profiling by RT-PCR (18)
Genotyping by array (17)
MicroRNA profiling by array (17)
DNA-seq (16)
ChIP-chip by array (13)
Human - High-throughput sequencing (10)
Methylation profiling by high throughput sequencing (10)
RNA-seq of total RNA (10)
Transcription profiling by SAGE (7)
Cell line - One-color microarray (7)
Proteomic profiling by array (7)
Human - One-color microarray (4)
Cell line - Single-cell sequencing (3)
High-throughput sequencing (3)
Animal - High-throughput sequencing (3)
ATAC-seq (3)
Single nucleus RNA sequencing (3)
Baseline (2)
MNase-seq (2)

Release Date

2022 (1957)
2021 (1795)
2023 (1631)
2025 (1627)
2020 (1469)
2024 (1352)
2019 (1172)
2015 (1043)
2016 (1042)
2017 (997)
2014 (955)
2018 (946)
2013 (820)
2012 (759)
2011 (619)
2010 (550)
2009 (346)
2008 (346)
2026 (251)
2007 (206)
2006 (100)
2005 (74)
2004 (44)
2003 (20)
2002 (18)
2000 (17)
2001 (13)
1999 (7)
1997 (5)
1998 (3)

Location

Spain (2)
Netherlands (2)
Australia (1)
Japan (1)
Italy (1)
Belgium (1)
China (1)
Germany (1)
United States (1)

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TGF-β uncouples glycolysis and inflammation in macrophages and controls the survival during sepsis

The mechanisms by which macrophage metabolism is regulated and the effects of metabolism on diseases remain largely unknown. We show here that TGF-β regulates the glycolysis of macrophages independently of inflammatory cytokine production, and thus affects the survival in experimental sepsis. Spe...

2023-02-17 | MTBLS6886 | MetaboLights

TGF-Beta 3 heterozygous mice

Not available

ORGANISM(S): Mus musculus

ST001303 | MetabolomicsWorkbench

HNF4A-binding sites in HepG2 hepatoblastoma cells treated with TGF-beta

Specific regulation of target genes by transforming growth factor-β (TGF-β) in a given cellular context is determined in part by transcription factors and cofactors that interact with the Smad complex. In the present study, we determined Smad2 and Smad3 (Smad2/3) binding regions in the promoters of ...

ORGANISM(S): Homo sapiens

2011-06-08 | E-GEOD-28845 | biostudies-arrayexpress

Untargeted Metabolomics analysis of A549 treated with 0.5 mM extracellular ATP and 10 ng/ml TGF-beta

Not available

ORGANISM(S): Homo sapiens

ST001779 | MetabolomicsWorkbench

Expression data from TGF-beta-treated human ovarian fibroblasts

Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Ovarian cancer cells are known to have diminished response to TGF-beta, but it remains unclear whether TGF-beta can modulate ovarian cancer cell growth in an indirect manner through cancer-associated fibroblasts ...

ORGANISM(S): Homo sapiens

2013-12-31 | E-GEOD-40266 | biostudies-arrayexpress

Human osteoblast treated with recombinant TGF-beta

Global expression profile of human osteoblast treated with recombinant TGF-beta compared to human osteoblast treated with growth media alone Dye-swap design with 6 biological replicates. Three arrays performed with TGF-beta treated samples on channel 1 and media-alone treated on channel 2; three arr...

ORGANISM(S): Homo sapiens

2010-09-29 | E-GEOD-17843 | biostudies-arrayexpress

Citrullination of latency-associated peptide of TGF beta1

Enzymatic citrullination of latency-associated peptide of TGF beta1 by PAD2

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

2016-10-04 | MSV000080224 | MassIVE

Transcription profiling of human pulp and odontoblasts reponse to TGF-beta1

Transforming growth factor beta 1 (TGF-Î²1) is the most extensively studied growth factor in dentin-pulp complex, with pleiotropic effects on pulp response and healing. Our main objective was to analyze the expression profile of pulp tissue and odontoblasts, and the effects of TGF-Î²1 on these profi...

ORGANISM(S): Homo sapiens

2008-06-16 | E-GEOD-8730 | biostudies-arrayexpress

Protection from obesity and diabetes by blockade of TGF-beta/Smad3 signaling

Imbalances in glucose and energy homeostasis are at the core of the worldwide epidemic of obesity and diabetes. Here, we illustrate an important role of the TGF-beta/Smad3 signaling pathway in regulating glucose and energy homeostasis. Smad3 deficient mice are protected from diet-induced obesity and...

ORGANISM(S): Mus musculus

2011-07-12 | E-GEOD-28598 | biostudies-arrayexpress

Transcription profiling of primary human macrophages treated with TGF-beta

The goal of the study was to identify the effects of TGF-beta on primary human macrophages maturated under different conditions. Experiment Overall Design: For the analysis of TGF-beta effects macrophages were differentiated in the presence of IL-4 or IL-4 in combination with dexamethasone. After 5 ...

ORGANISM(S): Homo sapiens

2008-06-20 | E-GEOD-7568 | biostudies-arrayexpress