therapeutic efficacy

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Organisms

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Viruses (1)
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Mesorhizobium metallidurans STM 2683 (1)
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Callithrix jacchus (1)
mouse gut metagenome (1)
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Organisms

Homo sapiens (1330)
Mus musculus (934)
Rattus norvegicus (48)
mouse gut metagenome (12)
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Sus scrofa (5)
Macaca mulatta (4)
Pseudomonas aeruginosa (4)
human gut metagenome (4)
Ovis aries (4)
unidentified (3)
Cavia porcellus (3)
Macaca fascicularis (3)
Saccharomyces cerevisiae (3)
Felis catus (3)
Canis lupus familiaris (3)
Escherichia coli (3)
Danio rerio (3)
mouse skin metagenome (2)
Chlorocebus sabaeus (2)
rat gut metagenome (2)
Caenorhabditis elegans (2)
Homo (2)
Plasmodium falciparum (2)
Acremonium egyptiacum (1)
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Marmota monax (1)
Chlorocebus aethiops (1)
Venezuelan equine encephalitis virus (1)
Platycodon grandiflorus (1)

Repository

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geo (2343)
biostudies-arrayexpress (385)
pride (331)
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jPOST (25)
dbGaP (8)
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GNPS (1)
GPMDB (1)
NODE (1)
PeptideAtlas (1)

Tissue

Cell culture (123)
Epithelial cell (28)
Brain (18)
Blood (15)
Lung (14)
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Stem cell (11)
B cell (9)
Liver (9)
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T cell (8)
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Type II pneumocyte (5)
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Embryonic stem cell (3)
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Malignant cell (3)
Mesothelial fibroblast (3)
Pancreas (1)

Disease

Colorectal Neoplasms (18)
Colorectal cancer (7)
Alzheimer's disease (4)
Neoplasms (3)
Colorectal cancer (2)
Cancers such as hepatocellular carcinoma, breast cancer, colorectal cancer and related gastrointestinal cancers, urologic cancers including prostate cancer, pancreas cancer, and lung cancer), on which a significant therapeutic efficacy of Huaier has been reported. Special remarks is emphasized on the cancer cases designated to be related to cancer stem cells (2)
Metastatic Colorectal Cancer (2)
Pancreatic Neoplasms (2)
Colonic Neoplasms (2)
Glucocorticoid-remediable aldosteronism (1)
Prostate cancer (1)
Ewing family tumor (1)
Early-life seizures (1)
Metastatic prostate cancer (1)
Myeloma (1)
Normal (1)
Colorectal cancer liver metastases (CRLM) (1)
Blood magnesium decreased (1)
Gastroesophageal Reflux (1)
Digestive System Fistula (1)
Solid cancers (1)
Colonic Polyps (1)
Solid tumour (1)
Stage IIIb colorectal cancer (1)
Metastatic colorectal cancer (adenocarcinoma) (1)
Pancreas, unspecified (1)
Gastric cancer (1)
Cancer (1)
Cholangitis (1)
Colorectal cancer, Gastric cancer, Esophageal cancer, Biliary tract cancer, Pancreatic cancer, and Other Solid cancer (1)

Technology Type

Mass Spectrometry (331)
Shotgun proteomics (121)
Bottom-up proteomics (103)
Mass spectrometry (66)
Mass spectrometry assay (55)
Data-dependent acquisition (50)
Data-independent acquisition (38)
Affinity purification coupled with mass spectrometry proteomics (35)
Gel-based experiment (17)
SWATH MS (10)
Top-down proteomics (10)
Illumina HiSeq 2000 (5)
Fluorescence imaging (5)
Fluorescence intensity (5)
NMR spectroscopy (3)
DiaPASEF (3)
HDMSE (3)
NMR spectroscopy assay (2)
Affinity proteomics (2)
All-ion fragmentation (2)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
Olink affinity proteomics (2)
ILLUMINA, Illumina HiSeq 1000 (1)
ILLUMINA, HiSeq X Ten (1)
ILLUMINA, NextSeq 500 (1)
ILLUMINA, Illumina HiSeq 2500 (1)
Illumina HiSeq 4000, Illumina HiSeq 2500, ILLUMINA (1)
GeneChip HTA 2.0 (1)
Illumina HiSeq 2000, Illumina Genome Analyzer II, ILLUMINA (1)
Illumina MiSeq (1)

Instrument Platform

Illumina NovaSeq 6000 (16)
Q Exactive Plus (10)
Illumina NovaSeq X (6)
NextSeq 500 (6)
DNBSEQ-G400 (5)
Illumina HiSeq 4000 (5)
Illumina HiSeq 2000 (3)
DNA Microarray Scanner BA [Agilent Technologies] (2)
NextSeq 2000 (2)
Illumina HiSeq 2000 platform (1)
In-house Perl scripts (1)
Sony MA-900 cell sorter (1)
ProFlex PCR system (1)
BD FACS ARIA III analyser (1)
Advanced Sequencing Facility (1)
Epidermal cells : Trypsin dissociation / Dermal cells :MACS Whole Skin Dissociation Kit (1)
Bio-Rad CFX96 Real-time System (1)
BD LSRFortessa (1)
10X Chromium Controller (1)
10x Genomics Chromium (1)
Agilent Scanner G2505 (1)
Ilumina HiScan H166 (1)
Not applicable (1)
Illumina iScan (1)
Affymetrix GeneChip Scanner 3000 7G (1)
NA (1)
Illumina MiSeq (1)
Illumina HiSeq 1500 (1)
Illumina HiSeq 2500 (1)
Unspecified (1)

Publication Date

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2026 (757)
2024 (468)
2023 (254)
2022 (226)
2021 (169)
2020 (136)
2013 (108)
2015 (88)
2019 (79)
2018 (62)
2012 (53)
2017 (52)
2014 (52)
2016 (50)
2011 (39)
2010 (34)
2009 (25)
2008 (22)
2007 (11)
2006 (5)
2004 (2)
2005 (1)

UNIPROT ID/AC

P01008 (2)
P10646 (2)
P12259 (2)
P00451 (2)
P00740 (2)
P00742 (2)
P08709 (2)
P13726 (2)
P00734 (2)
P62136 (2)
Q00987 (2)
P0CG47 (2)
P49841 (2)
Q13315 (2)
P04637 (2)
P05067 (2)
Q3UNK5 (1)
P70293 (1)
Q14609 (1)
C4NUM1 (1)
Q5STB3 (1)
O60346 (1)
Q16543 (1)
P07900 (1)
Q8N6C8 (1)
O00463 (1)
P20333 (1)
Q15750 (1)
Q9NYJ8 (1)
Q8N5C8 (1)

CHEBI ID

CHEBI:16704 (15)
CHEBI:17154 (15)
CHEBI:15891 (14)
CHEBI:16040 (14)
CHEBI:16919 (14)
CHEBI:30769 (14)
CHEBI:6650 (13)
CHEBI:17568 (13)
CHEBI:15428 (13)
CHEBI:16811 (12)
CHEBI:30746 (12)
CHEBI:18211 (12)
CHEBI:16761 (9)
CHEBI:16027 (9)
CHEBI:15422 (8)
CHEBI:68579 (2)
CHEBI:16991 (2)
CHEBI:26523 (2)
CHEBI:36916 (1)
CHEBI:72568 (1)
CHEBI:63637 (1)
CHEBI:75047 (1)
CHEBI:79091 (1)
CHEBI:65172 (1)
CHEBI:61033 (1)
CHEBI:28304 (1)
CHEBI:18059 (1)
CHEBI:16247 (1)
CHEBI:16618 (1)
CHEBI:18348 (1)

Metabolite Name

Adenosine (27)
Uridine (27)
Creatine (27)
Cytosine (25)
Riboflavin (25)
Hypoxanthine (25)
Choline (24)
Uracil (23)
Taurine (23)
Thymine (22)
Adenine (22)
Creatinine (21)
L-Phenylalanine (21)
Citrulline (20)
Cytidine (20)
Xanthine (20)
Guanosine (20)
Thymidine (20)
Inosine (20)
Betaine (19)
Ornithine (19)
Serotonin (19)
Guanine (19)
Spermidine (18)
Glycine (17)
Trigonelline (17)
Histamine (17)
L-Glutamine (17)
L-Tyrosine (17)
Thiamine (16)

First Public Date

2026 (830)
2025 (770)
2024 (482)
2023 (231)
2022 (207)
2021 (158)
2020 (129)
2014 (97)
2019 (88)
2018 (55)
2017 (51)
2015 (38)
2016 (22)
2013 (4)
2012 (2)

Modelling Approach

Ordinary differential equation model (19)
Computational model (2)
Delayed differential equation model (1)

Study status

Recruiting (20)
Completed (17)
Not provided (13)
Active, not recruiting (4)
Not yet recruiting (3)
Terminated (2)
Enrolling by invitation (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (5)
Thoracic Oncology Molecular Medicine Program Moffitt Cancer Center Tampa, FL, USA (4)
Cancer Science Institute of Singapore (CSI), National University of Singapore (NUS) (3)
Institute of Clinical Medicine in National Yang-Ming Chiao Tung University, Taiwan (Muh-Hwa Yang Lab) (3)
Instituto de Investigaciones Sanitarias de Santiago de Compostela (3)
Moffitt Cancer Center Tampa, FL, USA (3)
The Second Hospital of Dalian Medical University (3)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (3)
1State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China 2Department of Biochemistry and Molecular Biology, School of Life Sciences, Peking University, Beijing, China, Peking University, Beijing 100871, China (2)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (2)
Daglig leder, PROMEC Institutt for klinisk og molekylær medisin lars.hagen@ntnu.no 73598508 72573342 Laboratoriesenteret, 231.04.008, Øya, Erling Skjalgssons gate 1 (2)
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, 75390, TX, USA (2)
Department of Biological Engineering, MIT (2)
Department of Chemistry and Chemical Biology, Harvard University (2)
Department of Laboratory Medicine, Wiita Lab, University of California, San Francisco, USA (2)
Drug Discovery Moffitt Cancer Center Tampa, FL, USA (2)
George Washington University (2)
Harvard University (2)
Indiana University School of Medicine (2)
Institute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4 (2)
Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Division of Infection Medicine, Lund, Sweden (2)
Sichuan University (2)
The Institute of Cancer Research (2)
The Institute of Cancer Research, London (2)
1 Biomolecular Mass Spectrometry and Proteomics Group, Utrecht Institute for Pharmaceutical Science, Utrecht University, Utrecht, The Netherlands. 2 Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands 3 Mass Spectrometry and Proteomics Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands (1)
1 Department I of Internal Medicine, Center for Integrated Oncology (CIO) Köln-Bonn. 2 Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD) (1)
1 National Centre for Scientific Research “Demokritos”, Agia Paraskevi, Attica, Greece 2 Department of Chemistry, National and Kapodistrian University of Athens, Greece (1)
1)Department of Biomolecular Medicine, Ghent University, Ghent, Belgium 2)Center for Medical Genetics Ghent, Ghent University, Ghent, Belgium 4)Department of Pharmaceutics, Ghent University, Ghent, Belgium (1)
1. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA 2. UPMC Hillman Cancer Center, Pittsburgh, PA, USA 3. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA 4. Department of Neurology, University of North Carolina, Chapel Hill, NC, USA (lab head) (1)
1: Department of Molecular Biology, Division of Chemistry andBioanalytics, University of Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, Austria 2: Christian Doppler Laboratory for Innovative Tools for Biosimilar Characterization, University of Salzburg, Hellbrunner Strasse 34, 5020 Salzburg, Austria (1)

Keyword

Bevacizumab (5)
Irinotecan (4)
Metastatic (2)
Oxaliplatin (2)
Cetuximab (2)
Carbon Nanoparticle-Loaded Iron (1)
Ferroptosis (1)
Dose Limited Toxicity (1)
Single-arm (1)
Gut Hormones (1)
Bariatric Surgery (1)
Weight Loss Diets (1)
Anti-obesity Medications (1)
Endoscopic Metabolic and Bariatric Therapies (EMBT) (1)
Bariatric Endoscopy (1)
Intragastric balloon (IGB) (1)
Ablation Techniques (1)
Submucosal Tunneling Procedures (1)
Pylorus sparing antral myotomy (PSAM) (1)
Gastroplasty with endoscopic myotomy (GEM) (1)
Gastric peroral endoscopic myotomy (G-POEM) (1)
Tissue Plication (1)
Primary Obesity Surgery Endolumenal (POSE) (1)
Restorative Obesity Surgery Endoluminal (ROSE) (1)
Endoluminal sleeves (1)
Endoscopic Suturing (1)
Endoscopic Sleeve Gastroplasty (ESG) (1)
Laparoscopic adjustable gastric banding (LAGB) (1)
Laparoscopic sleeve gastrectomy (LSG) (1)
Roux-en-Y gastric bypass (RYGB) (1)

IsPrivate

False (25)

Submitter Keywords

Immuno-oncology (4)
FAIR-AIML (2)
Machine Learning Model (2)

Classification

bacteria (12)
protozoa (5)
viruses (4)
fungi (1)

Modification

4-tetrahydrothiazine-3-carboxylic acid (1)

Study type

Transcription profiling by array (262)
RNA-seq of coding RNA (47)
Interventional (42)
Proteomic profiling by array (17)
Observational (14)
RNA-seq of coding RNA from single cells (9)
ChIP-seq (7)
Methylation profiling by array (6)
Comparative genomic hybridization by array (5)
Transcription profiling by RT-PCR (4)
DNA-seq (4)
Observational patient registry (4)
Genotyping by array (3)
MicroRNA profiling by array (3)
RNA-seq of total RNA (3)
Unknown experiment type (2)
ChIP-chip by tiling array (2)
Human - One-color microarray (2)
Other (2)
Cell line - One-color microarray (1)
Transcription profiling by tiling array (1)
Spatial transcriptomics by high-throughput sequencing (1)
ATAC-seq (1)
Methylation profiling by high throughput sequencing (1)
RNA-seq of non coding RNA (1)

Release Date

2025 (8144)
2022 (5248)
2024 (5141)
2023 (4898)
2021 (4516)
2020 (3305)
2019 (2324)
2018 (1930)
2017 (1647)
2016 (1438)
2026 (1211)
2015 (1161)
2014 (918)
2013 (650)
2012 (456)
2011 (342)
2010 (237)
2009 (158)
2008 (116)
2007 (54)
2006 (46)
2005 (24)
2004 (11)
2003 (5)
2001 (4)
1999 (3)
1998 (2)
2002 (1)
1995 (1)
1993 (1)

Location

Japan (14)
China (10)
France (7)
United States (7)
Spain (5)
Italy (4)
Germany (4)
North America (3)
Australia (3)
United Kingdom (3)
Belgium (3)
Europe (2)
Canada (2)
Netherlands (2)
Finland (1)
Malaysia (1)
Iran (1)
Denmark (1)
Asia except Japan (1)
Puerto Rico (1)
Portugal (1)
Israel (1)
Austria (1)

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Clinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights

Synergistic modulation of the gutmicrobiome-liver-hostmetabolome axis associates withthe therapeutic efficacy ofDanlou tablet against metabolicsyndrome

Background: Obesity drives chronic diseases such as cardiovascular disease anddiabetes. Danlou tablet (DLT), a traditional Chinese medicine formula, is used totreat coronary heart disease by regulating lipid metabolism, suggesting potentialfor addressing obesity-related metabolic dysfunction. Howeve...

2026-06-12 | MTBLS14750 | MetaboLights

Plasma Metabolome Analysis for Predicting Antiviral Treatment Efficacy in Chronic Hepatitis B: Diagnostic Biomarkers and Therapeutic Insights

The early and accurate identification of predictive biomarkers for antiviral treatment efficacy remains a significant clinical challenge, particularly in the management of chronic hepatitis B (CHB). This study aimed to assess whether the plasma metabolome could reliably predict the success of antivi...

2024-07-10 | MTBLS10401 | MetaboLights

Integrated analysis of therapeutic efficacy and resistance mechanisms of lytic phages targeting ST218 K57 CR-hvKp

Clinical infection caused by carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is gradually increasing and spreading across the world, and phage therapy is a viable application as an alternative to antibiotics. However, additional clinical application is still restricted by the phag...

2025-09-18 | MTBLS12480 | MetaboLights

Donor Gut MicrobialDrives Fecal Microbiota Transplantation Efficacy in ulcerative colitis

Fecal microbiota transplantation (FMT) has emerged as a promising therapeutic strategy for Inflammatory Bowel Disease (UC), though its clinical success appears contingent upon donor microbiota engraftment degree. While microbial colonization dynamics remain poorly understood, our study identifies...

2026-01-11 | MTBLS12531 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria (E.coli;C.saccharolyticum;S.salivarius;E.rectale;L.plantarum;L.lactis assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1627 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria (B.animalis assays)

2021-07-20 | MTBLS1264 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria (L.saccharolytica;Standards assays)

2021-07-20 | MTBLS2885 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis (FIA-MS) (C.saccharolyticum;E.coli;L.plantarum;L.lactis;S.salivarius assays)

2021-07-20 | MTBLS1791 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria: duloxetine accumulation at different concentrations (L.saccharolytica;E.coli assays)

2021-07-20 | MTBLS1319 | MetaboLights