therapeutic target

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Organisms

Homo sapiens (4025)
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unidentified (8)
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human gut metagenome (6)
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mouse gut metagenome (4)
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Caenorhabditis elegans (4)
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synthetic construct (3)
Mammalia (3)
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Nothapodytes nimmoniana (2)
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mouse skin metagenome (2)
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Clostridioides difficile (2)
Candidozyma auris (2)
Mycobacterium intracellulare (2)
Severe acute respiratory syndrome coronavirus 2 (2)

Repository

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geo (6562)
biostudies-arrayexpress (2495)
pride (1737)
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Tissue

Cell culture (484)
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Anaplastic large cell lymphoma has DiseaseStaging II (1)
Invasive pituitary adenoma (1)
Oropharynx squamous-cell carcinoma in DiseaseLocation oropharynx has DiseaseStaging lymph node negative (N0) (1)
Gliosarcoma (1)
Chondroblastoma (1)
Metastatic prostate cancer (1)
No injury (1)
Hepatitis C infected (1)
"colon adenocarcinoma, acterial infection" (1)
Breast adenocarcinoma (1)
Perilesional skin (hair) (1)
Bladder cancer (1)

Technology Type

Mass Spectrometry (1737)
Shotgun proteomics (783)
Mass spectrometry (282)
Mass spectrometry assay (125)
NMR spectroscopy (14)
Illumina HiSeq 2000 (11)
Illumina HiSeq 2500 (4)
Fluorescence imaging (4)
Fluorescence intensity (4)
NMR spectroscopy assay (3)
Illumina HiSeq 2500, ILLUMINA (2)
Illumina HiSeq 2000, ILLUMINA (2)
Illumina CytoSNP, Illumina HumanOmni2.5, ILLUMINA, Illumina 450k, Illumina HiSeq 2000 (1)
ILLUMINA, Illumina HiSeq 1000 (1)
Illumina HiSeq 2000, Illumina Infinium HumanMethylation450 BeadChip, Affymetrix expression array, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 4000 (1)
ILLUMINA, Illumina HiSeq 4000, Illumina MiSeq (1)
Illumina HiSeq 2500, Illumina HiSeq 4000, ILLUMINA, NextSeq 500 (1)
Illumina MiSeq, ILLUMINA (1)
ILLUMINA, Illumina HiSeq 2500 (1)
Aperio (1)
Illumina HiSeq 1500 (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2500, ILLUMINA, Illumina MiSeq, Illumina HiSeq 2000 (1)
Illumina Genome Analyzer IIx, Illumina HiSeq 2000 (1)
Illumina HiSeq 2500, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, Illumina Genome Analyzer II (1)
Illumina Genome Analyzer II, Illumina HiSeq 2000 (1)
Illumina MiSeq (1)
Illumina Genome Analyzer II (1)

Instrument Platform

Illumina NovaSeq 6000 (93)
NextSeq 500 (30)
Illumina HiSeq 2500 (19)
Illumina HiSeq 2000 (19)
Illumina HiSeq 4000 (19)
NextSeq 2000 (12)
Illumina NovaSeq X (11)
NextSeq 550 (11)
Illumina MiSeq (8)
Dell PowerEdge R750; CPU: 2 × Intel Xeon Gold 6346 (32 Cores / 64 Threads); RAM: 188 GB (7)
NucleoSpin RNA/Protein kit lysis buffer (350 µL per tube; Macherey‑Nagel). (6)
DNBSEQ-G400 (6)
See manuscript (5)
DNBSEQ-T7 (5)
Illumina HiSeq 1500 (5)
FastPrep‑24 homogenizer (MP Biomedicals) (4)
PromethION (3)
Agilent 2100 Bioanalyzer (3)
FastPrep‑24 homogenizer (MP Biomedicals), operated at 5 m/s for 10 seconds. (2)
Element AVITI (2)
GeneChip Instrument System (2)
Affymetrix mouse gene 1.0 ST arrays (2)
Illumina Genome Analyzer IIx (2)
GenePix 4000B [Axon Instruments] (2)
Axon GenePix 4000B scanning hardware (2)
None (2)
N/A (2)
Illumina HiSeq 1000 (2)
Illumina HiSeq 2000 platform (1)
Agilent TapeStation (1)

Publication Date

2025 (1948)
2026 (1942)
2024 (1275)
2023 (904)
2022 (847)
2021 (607)
2020 (484)
2015 (418)
2014 (388)
2013 (388)
2012 (379)
2019 (369)
2016 (360)
2010 (360)
2011 (327)
2018 (312)
2017 (295)
2009 (163)
2008 (152)
2007 (54)
2006 (18)
2005 (16)
2003 (2)
2004 (1)
2027 (1)

UNIPROT ID/AC

P25799 (3)
P47811 (2)
O09110 (2)
P70236 (2)
Q9WUB0 (2)
Q91WA6 (2)
Q924T7 (2)
Q62073 (2)
Q60855 (2)
P70191 (2)
Q9WTK5 (2)
P39429 (2)
Q3U0V2 (2)
P25118 (2)
P70196 (2)
P20963 (2)
P35225 (2)
P78552 (2)
P29597 (2)
Q9Z1E3 (2)
P29350 (2)
P24394 (2)
P42229 (2)
P51692 (2)
O60674 (2)
Q9WTU6 (1)
Q91Y86 (1)
Q8CE90 (1)
P47809 (1)
Q99K90 (1)

ENSEMBL ID

ENSG00000168036 (1)
ENSG00000149968 (1)
ENSG00000033327 (1)
ENSG00000100985 (1)
ENSG00000102908 (1)
ENSG00000118260 (1)
ENSG00000163739 (1)
ENSG00000120659 (1)

CHEBI ID

CHEBI:30769 (80)
CHEBI:17368 (75)
CHEBI:16737 (70)
CHEBI:15891 (69)
CHEBI:16704 (68)
CHEBI:16335 (67)
CHEBI:15428 (65)
CHEBI:16919 (65)
CHEBI:17596 (65)
CHEBI:16708 (64)
CHEBI:32816 (63)
CHEBI:16027 (62)
CHEBI:17568 (61)
CHEBI:15741 (61)
CHEBI:30915 (59)
CHEBI:18237 (57)
CHEBI:18012 (57)
CHEBI:16750 (56)
CHEBI:17154 (56)
CHEBI:28044 (55)
CHEBI:15354 (55)
CHEBI:18211 (54)
CHEBI:33699 (4)
CHEBI:139356 (1)
CHEBI:86989 (1)
CHEBI:36916 (1)
CHEBI:72568 (1)
CHEBI:36080 (1)
CHEBI:59132 (1)
CHEBI:64297 (1)

Metabolite Name

Hypoxanthine (81)
Creatine (78)
Adenosine (75)
Creatinine (74)
Adenine (73)
Taurine (69)
Uridine (68)
Inosine (67)
Uracil (64)
Xanthine (64)
Choline (63)
L-Phenylalanine (58)
Cytidine (55)
Guanosine (55)
Guanine (53)
L-Tyrosine (53)
Cytosine (51)
L-Glutamine (50)
L-Proline (49)
Indole (48)
L-Tryptophan (48)
Betaine (47)
L-Histidine (47)
Ornithine (46)
Pantothenic acid (46)
Citric acid (45)
Riboflavin (44)
L-Valine (44)
Citrulline (43)
L-Threonine (43)

First Public Date

2026 (1601)
2025 (1538)
2024 (1097)
2023 (699)
2022 (594)
2014 (475)
2021 (435)
2020 (399)
2019 (291)
2017 (236)
2018 (197)
2015 (127)
2016 (116)
2013 (47)

Modelling Approach

Ordinary differential equation model (15)
Constraint-based model (5)
Logical model (2)
Other (1)
Agent-based model (1)
Physiologically based pharmacokinetic model (1)

Study status

Completed (5)
Not provided (4)
Recruiting (2)
Not yet recruiting (2)
Suspended (1)
Withdrawn (1)
Active, not recruiting (1)

Lab affiliation

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA (37)
University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (20)
IRCCS Istituto G Gaslini (11)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (10)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (6)
Department of Biochemistry, Sapporo Medical University School of Medicine (5)
Baylor College of Medicine (4)
Cancer Biology Department, Fox Chase Cancer Center, Philadelphia, PA, USA (4)
Functional Proteomics, ICR (4)
Institute of Molecular Biology (IMB), Mainz, Germany (4)
Moffitt Cancer Center Tampa, FL, USA (4)
Principal Investigator Centre for Targeted Protein Degradation, School of Life Sciences (4)
Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, SE-751 23 Uppsala, Sweden. (4)
The Institute of Cancer Research, London (4)
CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (3)
Cambridge Institute for Medical Research, University of Cambridge (3)
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver V5Z 1L3, Canada. (3)
Centre de recherche du Centre Hospitalier Universitaire (CHU) de Quebec-Université Laval, Québec, QC, Canada Centre de recherche sur le cancer de l’Université Laval, Québec, QC, Canada PROTEO-Quebec Network for Research on Protein Function, Engineering, and Applications, Québec, QC, Canada Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec, QC, Canada (3)
Department of Chemistry and Chemical Biology, Harvard University (3)
Department of Orthopedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou City, China. (3)
Departments of Surgery and Biomedical Sciences Cedars-Sinai Medical Center Los Angeles, CA 90048 (3)
Dept. of Laboratory Medicine, University of California, San Francisco, CA (3)
Edinburgh Cancer Research, CRUK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK (3)
Executive Science Officer, BioFrontiers InstituteDistinguished ProfessorProfessor, Howard Hughes Medical Institute MOLECULAR CELLULAR AND DEVELOPMENTAL BIOLOGY CU DENVER SCHOOL OF MEDICINE (3)
Head Proteomics Group, Leiden University Medical Center, Center for Proteomics and Metabolomics, PO Box 9600, Postal zone P1-Q, 2300 RC Leiden, The Netherlands (3)
Institute of Virology - Viral Immunopathology, Faculty of Medicine, Technical University Munich (3)
Institute of Virology, Technical University of Munich, Munich, Germany. (3)
Instituto de Investigaciones Sanitarias de Santiago de Compostela (3)
Laboratoire de Spectrométrie de Masse BioOrganique, Université de Strasbourg, CNRS, IPHC, UMR 7178, Strasbourg, France (3)
MRC PPU University of Dundee (3)

Keyword

Cetuximab (2)
Lycopene (1)
Anti EGFR therapy (1)
Salvage therapy (1)
HER-2 positive (1)
HER-2 ADC (1)
PD-1 inhibitor (1)
Second-line (1)
Wild type KRAS (1)
Gene transfer (1)
T cells (1)
Circulating cell free DNA (1)
Lomustine (1)
Refractory cancers (1)
9-ING-41 (1)
Glycogen Synthase Kinase (1)
GSK-3β (1)
NF-κβ (1)
Chemoresistance (1)
DNA damage response DDR (1)
Ataxia telangiectasia mutated and Rad3 related ATR (1)
Checkpoint kinase 1 CHK1 (1)
Checkpoint Inhibitor (1)
ATLL (1)
Genotyping (1)
Area-under-the concentration-time curve (1)
RAS-mutant (1)
Disitamab vedotin (1)
LAG-3 (1)
Albumin-Bound Paclitaxel (1)

IsPrivate

False (33)

Model Flag

Non Kinetic (6)

Submitter Keywords

FROG (4)
FAIR-AIML (1)
Machine Learning Model (1)
Immuno-oncology (1)
COVID-19 (1)

Classification

bacteria (18)
fungi (9)
viruses (7)
protozoa (7)
helminths (2)

Modification

2x(15)N labeled L-lysine (4)
4x(15)N labeled L-arginine (4)
4-tetrahydrothiazine-3-carboxylic acid (3)
15.994915 (2)
-17.026549 (1)
4'-dihydroxyphenylalanine (1)
42.010565 (1)
4x(2)H labeled dimethylated residue (1)
57.021464 (1)
6x(2)H labeled dimethylated L-arginine (1)

Study type

Transcription profiling by array (1769)
RNA-seq of coding RNA (286)
ChIP-seq (103)
Comparative genomic hybridization by array (42)
RNA-seq of non coding RNA (39)
Unknown experiment type (36)
RNA-seq of coding RNA from single cells (31)
Methylation profiling by array (22)
Other (20)
RNA-seq of total RNA (18)
Transcription profiling by RT-PCR (16)
MicroRNA profiling by array (14)
Genotyping by array (13)
Methylation profiling by high throughput sequencing (11)
Proteomic profiling by array (10)
DNA-seq (9)
ChIP-chip by tiling array (6)
Cell line - High-throughput sequencing (5)
Transcription profiling by tiling array (4)
RNAi profiling by array (4)
Transcription profiling by SAGE (2)
Animal - One-color microarray (2)
MicroRNA profiling by high-throughput sequencing (2)
Human - High-throughput sequencing (2)
Cell line - One-color microarray (2)
ChIP-chip by array (2)
MicroRNA profiling by high throughput sequencing (2)
ATAC-seq (2)
Hi-C (2)
RIP-seq (2)

Release Date

2025 (9748)
2022 (8742)
2021 (7935)
2023 (7894)
2024 (7003)
2020 (6251)
2019 (4440)
2018 (3803)
2017 (3428)
2016 (3078)
2015 (2598)
2014 (2125)
2013 (1561)
2026 (1417)
2012 (1305)
2011 (1059)
2010 (893)
2009 (583)
2008 (423)
2007 (199)
2006 (117)
2005 (79)
2004 (37)
2003 (30)
2002 (15)
2001 (7)
2000 (7)
1998 (7)
1997 (7)
1999 (5)

Location

France (4)
Spain (3)
United States (3)
Saudi Arabia (1)
Norway (1)
Denmark (1)
Portugal (1)
Australia (1)
United Kingdom (1)
Japan (1)
Italy (1)
Belgium (1)
Canada (1)
China (1)
Germany (1)
Netherlands (1)
Switzerland (1)

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Cholesterol metabolism regulates cartilage metabolic-inflammatory crosstalk by triggering osteocyte mitochondria transfer as a therapeutic target for osteoarthritis

Osteoarthritis (OA) is considered as a metabolic related inflammatory disease in the joint affecting both cartilage and subchondral bone. Cholesterol metabolism has been implicated in the pathogenesis of OA, yet the underlying mechanism still remains elusive. Understanding the role of cholesterol me...

2025-09-28 | MTBLS11733 | MetaboLights

Identification and validation of a glutamine metabolism-related gene signature as a diagnostic and therapeutic target in osteoarthritis through integrated multi-omics analysis

2025-12-13 | MTBLS13455 | MetaboLights

Rabbit plasma metabolomic analysis of Nitroproston: a multi target natural prostaglandin based-drug (Untargeted study)

INTRODUCTION: Nitroproston® is a novel multi-target drug bearing natural prostaglandin E2 (PGE2) and nitric oxide (NO)-donating fragments for treatment of inflammatory and obstructive diseases (i.e. asthma and obstructive bronchitis). OBJECTIVES: To investigate the effects of Nitroproston® adm...

2019-08-27 | MTBLS727 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria (E.coli;C.saccharolyticum;S.salivarius;E.rectale;L.plantarum;L.lactis assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1627 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria (B.animalis assays)

2021-07-20 | MTBLS1264 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria (L.saccharolytica;Standards assays)

2021-07-20 | MTBLS2885 | MetaboLights

Targeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention

Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...

2018-11-26 | MTBLS762 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis (FIA-MS) (C.saccharolyticum;E.coli;L.plantarum;L.lactis;S.salivarius assays)

2021-07-20 | MTBLS1791 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis for resting cells (B.uniformis;C.saccharolyticum assays)

2021-07-20 | MTBLS1757 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria: cross-feeding metabolite analysis (FIA-MS) (E.rectale;S.salivarius assays)

2021-07-20 | MTBLS1792 | MetaboLights