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ProteomicsRepurposing homoharringtonine for thyroid cancer therapy through TIMP1/FAK/PI3K/AKT signaling pathway
Homoharringtonine (HHT), an alkaloid isolated from Cephalotaxus, is an effective anti-leukemia agent that also exhibits inhibitory effects in various solid tumors. However, the impacts of HHT treatment on thyroid cancer (TC) remain unclear. This study aimed to explore whether HHT has anti-TC effects...
ORGANISM(S): Homo Sapiens 
2024-03-03 | PXD050295 |
GenomicsEffect of TIMP1 treatment on human VSMC gene expression
Effect of TIMP1 treatment on human VSMC gene expression
PRJNA1034045 | ENA
TranscriptomicsGPI-anchored Timp1 protein
Tissue inhibitor of metalloproteinase 1 (TIMP-1) controls matrix metalloproteinase (MMP) activity through 1:1 stochiometric binding. Human TIMP-1 fused to a glycosylphosphatidylinositol (GPI) anchor (TIMP-1-GPI) shifts the activity of TIMP-1 from the extracellular matrix to the cell surface. TIMP-1-...
ORGANISM(S): Homo sapiens 
2012-08-23 | E-GEOD-40301 | biostudies-arrayexpress
GenomicsEfferocytosis fuels malignant pleural effusion through TIMP1
Efferocytosis fuels malignant pleural effusion through TIMP1
PRJNA723335 | ENA
ProteomicsTIMP1 mediates astrocyte-dependent local immunosuppression in brain metastasis acting on infiltrating CD8+ T cells.
Immunotherapies against brain metastases have shown clinical benefits mainly when applied to locally asymptomatic patients. It is currently unclear why responses to this therapy drop in symptomatic brain metastases, since the use of corticoids is not consistently involved. We report here that a subp...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-27 | PXD040436 | Pride
Microenvironment Brain metastasis Immunotherapy 
GenomicsTIMP1-Mediated M2 Macrophage Polarization Facilitates Liver Metastasis in Colorectal Cancer
TIMP1-Mediated M2 Macrophage Polarization Facilitates Liver Metastasis in Colorectal Cancer
PRJNA1307398 | ENA
TranscriptomicsTIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression
High levels of Tissue Inhibitor of Metalloproteinases-1 (TIMP1) are associated with poor prognosis, reduced response to chemotherapy, and, potentially, also poor response to endocrine therapy in breast cancer patients. Our objective was to further investigate the hypothesis that TIMP1 is associated ...
ORGANISM(S): Homo sapiens 
2013-08-22 | E-GEOD-35535 | biostudies-arrayexpress
TranscriptomicsTIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression
High levels of Tissue Inhibitor of Metalloproteinases-1 (TIMP1) are associated with poor prognosis, reduced response to chemotherapy, and, potentially, also poor response to endocrine therapy in breast cancer patients. Our objective was to further investigate the hypothesis that TIMP1 is associated ...
ORGANISM(S): Homo sapiens 
2013-08-22 | GSE35535 | GEO
GenomicsSevere infection constitutively upregulates TIMP1 in the bone marrow hematopoietic niche to support long-term enhanced myelopoiesis
Severe infection constitutively upregulates TIMP1 in the bone marrow hematopoietic niche to support long-term enhanced myelopoiesis
PRJNA847242 | ENA
TranscriptomicsEffect of TIMP1 treatment on human VSMC gene expression
Human VSMC isolates generated from aortic explants were treated in serum free media, +/- the addition of 500 ng / mL TIMP1 for 6 hours
ORGANISM(S): Homo sapiens 
2024-04-09 | GSE246647 | GEO
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