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MetabolomicsRapid biotransformation of STW 5 constituents by human gut microbiome from IBS- and non-IBS donors

STW 5, a blend of 9 medicinal plant extracts, exhibits promising efficacy in treating functional gastrointestinal disorders, notably irritable bowel syndrome (IBS). Nonetheless, its effects on the gastrointestinal microbiome and the role of microbiota on the conversion of its constituents are sti...

2024-05-07 | MTBLS2398 | MetaboLights
MetabolomicsGut microbiota carcinogen metabolism causes distal tissue tumours

Exposure to environmental pollutants and human microbiome composition are important predisposition factors for tumour development. Similar to drug molecules, pollutants are typically metabolised in the body, which can change their carcinogenic potential and impact tissue distribution through alte...

2024-06-05 | MTBLS3581 | MetaboLights
MetabolomicsIdentification of Cetobacterium somerae as a key contributor to muscle quality improvement through intestinal microbiota transplantation from faba bean-fed donors in Yellow River carp (Cyprinus carpio)

Background The gut microbiota plays a significant role in modulating the growth and function of host muscle, and microbiota transplantation experiments provide compelling evidence of its capacity to improve muscle quality. Feeding faba beans improves the muscle quality of Yellow River carp. ...

2025-10-13 | MTBLS13128 | MetaboLights
MetabolomicsIntegrated Multi-Omics Mapping of Mitochondrial Dysfunction and Substrate Preference in Barth Syndrome Cardiac Tissue

Barth syndrome (BTHS) is a rare X-linked recessively inherited disorder caused by variants in the TAFAZZIN gene. The pathogenic variants lead to impaired conversion of monolysocardiolipin (MLCL) into mature phospholipid cardiolipin (CL). The accumulation of MLCL and mature CL deficiency is a diag...

2025-09-08 | MTBLS12953 | MetaboLights
ProteomicsBlood plasma and serum samples of healthy donors fractionated on different chromatography sorbents
Blood as connective tissue potentially contain evidence of all processes occurring within the organism, at least in trace amounts. Because of their small size, peptides overcome cell membranes and epithelial barriers more freely than proteins. Among the peptides found in blood, there are both fragme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-15 | MSV000081717 | MassIVE
ProteomicsSite-specific glycosylation mapping of Fc gamma receptor IIIb from neutrophils of individual healthy donors
The uploaded dateset corresponds to MS1 and MS2 spectra obtained for Fc gamma receptor IIIb isolated from neutrophils of individual healthy donors. They represent NA1/NA2, NA2/NA2, NA2/NA2 allotype respectively. Based on the data, the targeted analysis of the N-glycosylation has been performed for t...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-08-05 | MSV000085913 | MassIVE
MetabolomicsGlobal 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo
Liver metabolism is central to human physiology and influences the pathogenesis of common metabolic diseases. Yet, our understanding of human liver metabolism remains incomplete, with much of current knowledge based on animal or cell culture models that do not fully recapitulate human physiology. He...
2024-07-23 | MTBLS10481 | MetaboLights
TranscriptomicsSingle cell RNA and CITE sequencing of cells from synovial tissue biopsies of healthy donors, and Rheumatoid Arthritis (RA) patients with active disease or sustained clinical remission
The dataset includes the raw FASTQ files generated from the 10x Genomics Single Cell 3’ v3.1 experiments. For samples processed with TotalSeq Hashtag reagents, the corresponding hashtag oligonucleotide and condition annotations are provided as separate .csv files. The processed matrices contain filt...
ORGANISM(S): Homo sapiens 
2024-12-06 | E-MTAB-14213 | biostudies-arrayexpress
TranscriptomicsFKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance.
Glucocorticoid excess is linked to central obesity, adipose tissue insulin resistance and type 2 diabetes mellitus. The aim of our study was to investigate the effects of dexamethasone on gene expression in human subcutaneous and omental adipose tissue, in order to identify potential novel mechanism...
ORGANISM(S): Homo sapiens 
2014-08-18 | E-GEOD-42902 | biostudies-arrayexpress
GenomicsNext Generation Sequencing facilitates to identify the differential expression genes of liver tissue from HBVN donors, HBVP donors, LF donors and transplant donors.
Next Generation Sequencing facilitates to identify the differential expression genes of liver tissue from HBVN donors, HBVP donors, LF donors and transplant donors.
PRJNA923663 | ENA
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