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GenomicsLineage-Specific TOP2A Cleavage Landscape in Leukemia Cell
Lineage-Specific TOP2A Cleavage Landscape in Leukemia Cell
PRJNA412503 | ENA
GenomicsMYC modulates TOP2A diffusion to promote substrate detection and activity [CAD-seq]
MYC modulates TOP2A diffusion to promote substrate detection and activity [CAD-seq]
PRJNA1268393 | ENA
GenomicsTop2a promotes the development of social behavior via PRC2 and H3K27me3
Top2a promotes the development of social behavior via PRC2 and H3K27me3
PRJNA753112 | ENA
GenomicsMYC modulates TOP2A diffusion to promote substrate detection and activity [SLAM-seq]
MYC modulates TOP2A diffusion to promote substrate detection and activity [SLAM-seq]
PRJNA1370020 | ENA
GenomicsLineage-Specific TOP2A Cleavage Landscape in Leukemia Cell
Topoisomerases II (TOP2) play role in relief of torsional stress during DNA replication and gene transcription, and TOP2 is also a target of anticancer agents which cause secondary leukemia. To address cell lineage-specific TOP2A cleavage relative to leukemia, here we profile genome-wide TOP2A cleav...
ORGANISM(S): Homo sapiens 
2023-12-31 | GSE104384 | GEO
GenomicsTOP2A & TOP2B occupancy in MCF7 plus and minus estradiol by ChiP-seq
TOP2A & TOP2B occupancy in MCF7 plus and minus estradiol by ChiP-seq
PRJNA1484442 | ENA
GenomicsPRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve tumor
PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve tumor
PRJNA887699 | ENA
GenomicsLandscape of TOP2A-mediated DNA cleavage across the human genome
Type II topoisomerases orchestrate proper DNA topology and they also are the targets of anticancer drugs that cause leukemias with balanced translocations as secondary cancers. Here, we develop a novel high-throughput sequencing technology to define TOP2 cleavage sites at single base precision in hu...
ORGANISM(S): Homo sapiens 
2017-03-08 | GSE79593 | GEO
TranscriptomicsTop2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer
We perform RNA-seq on matched orthotopic murine primary and metastatic prostate cancer samples to identify differential gene expressions RNA-seq was performed on orthotopic murine primary and metastatic tumor samples using Illumina Hi-Seq 2000 platform
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-64771 | biostudies-arrayexpress
GenomicsTop2a Differentially Modulates Promoter Activity in Embryonic Stem Cells via Trim28 Recruitment and PRC2 Displacement [RNA-Seq]
Top2a Differentially Modulates Promoter Activity in Embryonic Stem Cells via Trim28 Recruitment and PRC2 Displacement [RNA-Seq]
PRJNA1080456 | ENA
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