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MetabolomicsSeed Metabolome Analysis of a Transgenic Rice Line Expressing Cholera Toxin B-subunit
Rice (Oryza sativa L.) is a candidate crop for production of plant-based vaccines by genetic engineering technologies. MucoRice-CTB has been developed as a rice-seed-based vaccine against cholera by transgenic expression of modified cholera toxin B-subunit (CTB) under the RNA interference (RNAi)-med...
2017-08-30 | MTBLS437 | MetaboLights
TranscriptomicsReceptors are affected by selection with each Bacillus thuringiensis israelensis Cry toxin but not with the full Bti mixture in Aedes aegypti
Bacillus thuringiensis israelensis (Bti) toxins are increasingly used for mosquito control, but little is known about the precise mode of action of each of these toxins, and how they interact to kill mosquito larvae. By using RNA sequencing, we investigated change in gene transcription level and pol...
ORGANISM(S): Aedes aegypti 
2019-05-16 | E-MTAB-7970 | biostudies-arrayexpress
TranscriptomicsM. smegmatis vapBC::aphA-3 M-NM-^TvapBC mutant (JR121) harboring tetracycline inducible vector pMind containing the vapBC operon (pJR230) and the pMind vector containing the vapC toxin gene (pJR29)
Transcriptional profiling of M. smegmatis JR121 expressing VapC and VapBC grown in flasks on Hartmans de Bont medium supplemented with 0.2% glycerol Comparing transcriptional response of strain JR121 to conditional expression of VapC toxin compared with the expression of VapBC complex. Biological re...
ORGANISM(S): Mycobacterium smegmatis 
2012-06-14 | E-GEOD-29631 | biostudies-arrayexpress
ProteomicsFunctional Dissection of the Retrograde Shiga Toxin Trafficking Inhibitor Retro-2
The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation in early endosomes, and the relocalization of the Golgi SNARE protein syntaxin-5 to the endoplasmic reticulum. The molecular mechanisms by wh...
ORGANISM(S): Homo sapiens (Human) 
2020-02-24 | PXD015642 | Pride
Er exit site Sec16a Retro-2 Syntaxin5 Shiga toxin Mass spectrometry Retrograde transport 
TranscriptomicsBacteroides (Phocaeicola)-driven metabolic remodelling suppresses Clostridioides difficile toxin expression in mixed biofilm communities
The aim of this study was to investigate transcriptomic changes in Clostridioides difficile when cultured as monoculture biofilms or as co-culture biofilms with either Bacteroides (Phocaeicola) dorei or Bacteroides (Phocaeicola) vulgatus. This study was also interested in transcriptomic changes occu...
ORGANISM(S): Phocaeicola vulgatus 
2026-09-23 | E-MTAB-15641 | biostudies-arrayexpress
ProteomicsRegulation of Toxin-Antitoxin System savRS in Staphylococcus aureus Virulence and Host Key Signaling pathway
Staphylococcus aureus is an important pathogen with strong pathogenicity and serious threat to public health. The toxin-antitoxin system is considered to be contributed to the pathogenicity of S. aureus, but the exact pathogenic mechanism remains unknown. Our previous study showed that toxin-antitox...
ORGANISM(S): Mus Musculus 
2024-12-25 | PXD059235 |
ProteomicsIgE antibodies increase honeybee venom responsiveness and detoxification efficiency of mast cells
In contrast to their clearly defined roles in allergic diseases, the physiologic functions of Immunoglobulin E antibodies (IgEs) and mast cells (MCs) remain enigmatic. Recent research supports the toxin hypothesis, showing that MCs and IgE-related type 2 immune responses can enhance host defense aga...
ORGANISM(S): Homo sapiens (Human) Apis mellifera (Honeybee) 
2021-11-25 | PXD023851 | Pride
Honeybee venom  host defense  ige  mast cells  toxin hypothesis 
UnknownDevelopment of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.
Not available
S-EPMC3477282 | biostudies-literature
GenomicsReceptors are affected by selection with each Bacillus thuringiensis israelensis Cry toxin but not with the full Bti mixture in Aedes aegypti
Receptors are affected by selection with each Bacillus thuringiensis israelensis Cry toxin but not with the full Bti mixture in Aedes aegypti
PRJEB32622 | ENA
TranscriptomicsMKK2 is sufficient but not necessary for proliferation and anchorage-independent growth of SK-MEL-28 cells.
Though mitogen activated protein kinase kinases (MKK or MEK) 1 and 2 are widely assumed to be functionally redundant some reports indicate they possess distinct biologic activities. To test the hypothesis that MEK1 and MEK2 signaling pathways are interchangeable we used two complementary approaches...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-23930 | biostudies-arrayexpress
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