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GenomicsTRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism
DNA lesions encountered by replicative polymerases threaten genome stability and cell cycle progression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitin ligase, in patients with microcephalic primordial dwarfism/Seckel syndrome. We establish that TRAIP relocali...
EGAS00001001501 | EGA
ProteomicsTRAIP regulates DNA double-strand break-induced ATM activation
TRAIP is a functional E3 ubiquitin ligase with a RING finger domain at the N-terminal end. To find TRAIP partners and substrates we used a proximity-dependent biotinylation assay (Bio-ID) which can identify direct protein-protein interaction but also proteins building a complex without requiring di...
ORGANISM(S): Homo sapiens (Human) 
2024-05-07 | PXD006715 | Pride
Human cells Protein interactions Dna damage Orbitrap Proximity labelling Bioid Tandem ms 
GenomicsTRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC
TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC
PRJNA993280 | ENA
Genomicsena-DATASET-MRCHGUIGMM-07-10-2015-09:16:27:050-356 - samples
BAM files for two WES TRAIP patients
EGAD00001001633 | EGA
TranscriptomicsTRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC
Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRAIP), a RING domain-containing E3 ligase, has emerged as a key player in safeguarding genome integrity and is closely linked to cancer. Here, we discovered that TRAIP exhibits low expression in bladder cancer (BLCA)...
ORGANISM(S): Homo sapiens 
2023-12-28 | GSE237002 | GEO
ProteomicsPhosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS
Chemical cross-linking coupled to mass spectrometry was used to study the structure and homodimerization of the E3 ubiquitin ligase TRAIP from Xenopus laevis. The protein was cross-linked with two different concentrations of disuccinimidyl suberate (DSS).
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-06-27 | PXD058941 | Pride
Chemical cross-linking  dss  traip 
GenomicsUbiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication – transcription conflicts 
Cell division is the basis for the propagation of life and requires accurate duplication of all genetic information. DNA damage created during replication (replication stress) is a major cause of cancer, premature aging and a spectrum of other human disorders. TRAIP E3 ubiquitin ligase has been show...
ORGANISM(S): Homo sapiens 
2023-09-01 | GSE201158 | GEO
UnknownUSP37 prevents premature disassembly of stressed replisomes by TRAIP.
Not available
S-EPMC11398331 | biostudies-literature
UnknownTRAIP regulates replication fork recovery and progression via PCNA.
Not available
S-EPMC4923944 | biostudies-literature
UnknownZNF212 promotes genomic integrity through direct interaction with TRAIP.
Not available
S-EPMC9881131 | biostudies-literature
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