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ProteomicsDifferent SWI/SNF complexes coordinately promote R-loop- and RAD52- dependent transcription-coupled homologous recombination
The SWI/SNF family of ATP-dependent chromatin remodeling complexes are implicated in multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF and PBAF complexes are two major types of SWI/SNF complexes that are functionally distinguished by their exclusive subunits. Accumula...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD035140 | Pride
Swi/snf  transcription-coupled homologous recombination  r-loops  rad52  dna damage response  arid1a  arid1b  brg1  brm 
TranscriptomicsThe DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination
Class-switch recombination (CSR), induced by activation-induced cytidine deaminase, can be divided into two phases: DNA cleavage of the switch (S) regions, and the joining of the cleaved ends of the different S regions. Here, we show that the DSIF complex (Spt4 and Spt5), a transcription elongation ...
ORGANISM(S): Mus musculus 
2013-10-22 | E-GEOD-33206 | biostudies-arrayexpress
UnknownDe novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.
Not available
S-EPMC6614800 | biostudies-literature
UnknownTranscription-coupled donor DNA expression increases homologous recombination for efficient genome editing.
Not available
S-EPMC9638910 | biostudies-literature
UnknownABL1-mediated tyrosine phosphorylation of SYCP2 contributes to transcription-coupled homologous recombination and platinum resistance in ovarian cancer.
Not available
S-EPMC12409405 | biostudies-literature
UnknownFMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation.
Not available
S-EPMC8944906 | biostudies-literature
UnknownROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB.
Not available
S-EPMC6175878 | biostudies-literature
UnknownDifferent SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination.
Not available
S-EPMC10516656 | biostudies-literature
UnknownLC3B drives transcription-associated homologous recombination via direct interaction with R-loops.
Not available
S-EPMC11109984 | biostudies-literature
UnknownThe histone chaperone CAF-1 prevents homologous recombination-mediated instability of the budding yeast ribosomal DNA during replication-coupled DNA double-strand break repair.
Not available
S-EPMC12657057 | biostudies-literature
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