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MetabolomicsAccumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex
Secondary metabolites are involved in the plant stress response. Among these are scopolin and its active form scopoletin, which are coumarin derivatives associated with reactive oxygen species scavenging and pathogen defence. Here we show that in Arabidopsis thaliana, scopolin accumulation can be in...
2018-02-05 | MTBLS389 | MetaboLights
TranscriptomicsExpression data from Saccharomyces cerevisiae strains deleted for different subunits of the THO/TREX complex
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis at the interface of transcription-RNA export with a key role in preventing transcription-associated genome instability. We used microarrays to analyze the impact of different THO/TREX mutations on gene expression and found tha...
ORGANISM(S): Saccharomyces cerevisiae 
2011-06-28 | E-GEOD-24802 | biostudies-arrayexpress
TranscriptomicsExpression data from Saccharomyces cerevisiae strains deleted for the THSC/TREX-2 subunits Thp1, Sac3 and Sus1
Transcription is a major obstacle for replication fork progression and a cause of genome instability. Such instability increases in mutants with a suboptimal assembly of the nascent messenger ribonucleo-protein particle (mRNP), as THO/TREX and the NPC-associated THSC/TREX-2 complex. We used microarr...
ORGANISM(S): Saccharomyces cerevisiae 
2014-10-08 | E-GEOD-56702 | biostudies-arrayexpress
GenomicsiCLIP of components of the TREX complex
iCLIP of components of the TREX complex
PRJNA454386 | ENA
TranscriptomicsThe nuclear pore-associated TREX-2 complex employs the Mediator Med31 submodule as a docking site to regulate gene expression
Nuclear pore complexes (NPCs) influence gene expression besides their established function in nuclear transport. The TREX-2 complex localizes to the NPC basket and affects gene-NPC interactions, transcription and mRNA export. How TREX-2 regulates the gene expression machinery is unknown. Here, we sh...
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-27 | E-GEOD-67431 | biostudies-arrayexpress
GenomicsChIP-seq of TREX complex proteins in HEK293T cells
ChIP-seq of TREX complex proteins in HEK293T cells
PRJNA542257 | ENA
GenomicsThe m 6 A-methylase complex recruits TREX and regulates mRNA export.
The m 6 A-methylase complex recruits TREX and regulates mRNA export.
PRJNA438473 | ENA
GenomicsTranscription and export complex (THO/TREX) coordinates transcription termination in Arabidopsis
Transcription and export complex (THO/TREX) coordinates transcription termination in Arabidopsis
PRJNA529202 | ENA
ProteomicsStructural analysis of the native TREX complex from S. cerevisiae
Chemical cross-linking coupled to mass spectrometry was used to study the endogenously purified S. cerevisiae TREX complex. Cross-linking was performed using (a) bis(sulfosuccinimidyl) suberate (BS3) or (b) a combination of adipic dihydrazide (ADH) and 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-09-15 | PXD025843 | Pride
Chemical cross-linking  bs3  adh  dmtmm  structural proteomics  protein complex  trex complex Tho complex 
TranscriptomicsThe m 6 A-methylase complex recruits TREX and regulates mRNA export.
N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this phenomenon remain poorly understood. Here we show that the m6A complex (WTAP, KIAA1...
ORGANISM(S): Homo sapiens 
2018-10-03 | GSE111878 | GEO
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