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ProteomicsSDH deficiency-driven succinate accumulation dictates the drug resistance of AML through regulating p-UBC12/cullin activity
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct microenvironment-associated metabolic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD053722 | Pride
Sdh deficiency  succinate  drug resistance  ubc12 phosphorylation  acute myeloid leukemia 
ProteomicsSDH deficiency-driven succinate accumulation dictates the drug resistance of AML through regulating p-UBC12/cullin activity
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct microenvironment-associated metabolic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD047175 | Pride
Sdh deficiency  succinate  drug resistance  ubc12 phosphorylation  acute myeloid leukemia. 
TranscriptomicsSuccinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct microenvironment-associated metabolic pro...
ORGANISM(S): Homo sapiens 
2024-08-27 | GSE247623 | GEO
UnknownSrc phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase.
Not available
S-EPMC4330765 | biostudies-literature
UnknownSuccinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation.
Not available
S-EPMC11560925 | biostudies-literature
UnknownBlocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.
Not available
S-EPMC5577376 | biostudies-literature
UnknownA Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination.
Not available
S-EPMC18275 | biostudies-literature
UnknownNedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.
Not available
S-EPMC85397 | biostudies-literature
GenomicsSuccinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
PRJNA1039834 | ENA
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