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Metabolomics1H NMR metabolomic and transcriptomic analyses reveal urinary metabolites as biomarker candidates in response to protein undernutrition in adult rats

BACKGROUND: Protein undernutrition is prevalent mainly among elderly people, and it could develop diseases such as sarcopenia. Urinary metabolites may become biomarkers reflecting protein undernutrition, but this has been insufficiently investigated.

OBJECTIVE:

2021-05-27 | MTBLS1452 | MetaboLights
MetabolomicsCross-feeding between intestinal pathobionts promotes their overgrowth during undernutrition
Not available
ORGANISM(S): Bacteroides spp. and Escherichia spp. (mixed communities) 
ST001862 | MetabolomicsWorkbench
ProteomicsCharacterization of the skeletal muscle proteome in under-nourished old rats
Therefore, undernutrition is common in the elderly where its prevalence varies from 4 to 10% at home, from 15 to 30% in care homes and reaches 30 to 70% in hospitals de-pending on the diagnostic criteria used [10]. Most of all, aging impairs the ability to adapt to undernutrition leading to severe l...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-06-09 | PXD032044 | Pride
Skeletal muscle  aging  sarcopenia  undernutrition  proteome 
TranscriptomicsMeDIP-seq of ICR mouse sperm with different combinations of in utero undernutrition and postnatal undernutrition
Maternal caloric restriction during the last week of gestation resulted in low birth weight (LBW) and increased risk of LBW-associated metabolic diseases in adult life. The metabolic phenotypes transmitted to F2 generation by paternal manner without additional altered nutrition. To investigate the ...
ORGANISM(S): Mus musculus 
2024-08-25 | E-MTAB-9567 | biostudies-arrayexpress
TranscriptomicsEffect of in utero undernutrition on skeletal muscle gene expression
In utero undernutrition is associated with obesity and insulin resistance, although its effect on skeletal muscle remains poorly defined. We report that, in mice, adult offspring from undernourished dams have decreased energy expenditure, decreased skeletal muscle mitochondrial content, and altered ...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-53520 | biostudies-arrayexpress
UnknownMaternal and child undernutrition: consequences for adult health and human capital.
Not available
S-EPMC2258311 | biostudies-literature
GenomicsMeDIP-seq of ICR mouse sperm with different combinations of in utero undernutrition and postnatal undernutrition
MeDIP-seq of ICR mouse sperm with different combinations of in utero undernutrition and postnatal undernutrition
PRJEB40330 | ENA
GenomicsILC1 quiescence confers protection against MCMV infections during undernutrition
ILC1 quiescence confers protection against MCMV infections during undernutrition
PRJNA1266082 | ENA
GenomicsMaternal undernutrition exacerbates microbiota-driven growth stunting through pre and postnatal effects
Maternal undernutrition exacerbates microbiota-driven growth stunting through pre and postnatal effects
PRJEB86068 | ENA
TranscriptomicsILC1 quiescence confers protection against MCMV infections during undernutrition
In the liver, group 1 innate lymphoid cells (ILCs) comprise 10–20% tissue-resident ILC1 cells and 80–90% conventional NK cells. Both cells contribute to early defense against virus infection by secreting IFN-γ. However, the distinct role of ILC1 cells in viral infections remains incompletely underst...
ORGANISM(S): Mus musculus 
2025-12-02 | GSE297741 | GEO
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