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MetabolomicsHarnessing microbial-derived metabolites in the urinary tract to prevent infection induced catheter encrustation

Proteus mirabilis is a predominant cause of catheter associated urinary tract infection (CAUTI), and a key virulence factor is its urease enzyme which hydrolyzes urea to ammonia. This process results in the formation of urinary stones, facilitating catheter blockage and bacteremia. The o...

2025-08-29 | MTBLS891 | MetaboLights
TranscriptomicsTranscriptome of Proteus mirabilis in the murine urinary tract
The enteric bacterium Proteus mirabilis is a common cause of complicated urinary tract infections. In the study, microrarrays were used to analyze P. mirabilis gene expression in vivo from experimentally infected mice. Urine was collected at 1, 3, and 7d postinfection, and RNA was isolated from bac...
ORGANISM(S): Proteus mirabilis 
2011-11-29 | E-GEOD-25977 | biostudies-arrayexpress
ProteomicsCharacterization of Early-Phase Neutrophil Extracellular Traps in Urinary Tract Infections
Neutrophils have an important role in rapid antimicrobial defenses against and resolution of urinary tract infections (UTIs). We show that a mechanism known as neutrophil extracellular trap (NET) formation is a strategy to combat pathogens in the urinary tract. Viscous aggregates that were present i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080847 | MassIVE
ProteomicsA Metaproteomics Approach to Elucidate Host and Pathogen Protein Expression during Catheter-Associated Urinary Tract Infections
Long term-catheterization leads inevitably to a catheter-associated bacteriuria caused by multispecies bacterial biofilms growing on and in the catheters. The overall goal of the presented study was (I) to unravel bacterial community structure and function of such an uropathogenic biofilm and (II) t...
ORGANISM(S): Morganella <scale Insect> (ncbitaxon:108061) Morganella <fungus> (ncbitaxon:90690) Pseudomonas Sp. (ncbitaxon:306) Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079927 | MassIVE
ProteomicsUrinary bacteriophage cooperation with bacterial pathogens during human urinary tract infections supports lysogenic phage therapy
Despite much promise to overcome drug-resistant infections, clinical studies of bacteriophage anti-bacterial therapy have failed to show durable effectiveness. Although lysogeny plays an important role in bacterial physiology, its significance in diverse microbiomes remains under-studied. Here, we t...
ORGANISM(S): Homo sapiens (Human) 
2025-01-17 | PXD059932 | Pride
Urinary tract infection Bacteriphages 
TranscriptomicsEscherichia coli global gene expression in urine from women with urinary tract infection
Examination of E. coli transcripts present in bacteria in urine samples from 8 patients attending a urology clinic with symptoms of cystitis, as compared to transcripts present in the same E. coli strains during mid-exponential growth in filter-sterilized human urine in vitro. A 48 array study using...
ORGANISM(S): Escherichia coli 
2010-11-12 | E-GEOD-24478 | biostudies-arrayexpress
TranscriptomicsMicrocolony-seq applied on a clinical urinary tract infection
Urine was obtained from a patient with a urinary tract infection and frozen in 15% glycerol at -80C. For the Microcolony-seq experiment a sample from the frozen urine was serially diluted four times 10-fold and plated on an LB agar plates and incubated at 37C. After 8 hours of incubated microcolonie...
ORGANISM(S): mixed sample 
2025-08-27 | E-MTAB-13892 | biostudies-arrayexpress
TranscriptomicsComparative Genomics of Urinary Tract Infectious Escherichia coli
Comparative genomic analysis of a range of urinary tract and urosepsis E.coli isolates
ORGANISM(S): Escherichia coli 
2011-05-20 | E-MEXP-3089 | biostudies-arrayexpress
ProteomicsHuman Urinary Proteome in Vesicoureteral Reflux
Vesicoureteral reflux (VUR) is a common pediatric condition that predisposes children to renal damage after urinary tract infection (UTI). We profiled the urinary proteome of VUR patients with recurrent UTI and renal scarring to identify potential biomarkers characterizing this condition. Urine was...
ORGANISM(S): Homo sapiens (Human) 
2018-10-05 | PXD010469 | Pride
Kidney damage Urine Vesicoureteral reflux Urinary tract infection 
ProteomicsPeptide signature for the fast detection of bacterial species in Urinary Tract infections using LC-MS
The fast identification of microbial species in clinical samples is essential to provide an appropriated antiobiotherapy to the patient and to reduce the prescription of broad spectrum antimicrobials leading to antibioresistances. We have developed a new strategy for the fast identification of bacte...
ORGANISM(S): Streptococcus Agalactiae 2603v/r Enterococcus Faecalis V583 Klebsiella Pneumoniae Subsp. Pneumoniae Mgh 78578 Escherichia Coli K-12 
2019-10-09 | PXD014970 | panorama
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