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MetabolomicsOsmolality-based normalization enhances statistical discrimination of untargeted metabolomic urine analysis: results from a comparative study

INTRODUCTION: Because of its ease of collection, urine is one of the most commonly used matrices for metabolomics studies. However, unlike other biofluids, urine exhibits tremendous variability that can introduce confounding inconsistency during result interpretation. Despite man...

2023-09-04 | MTBLS1765 | MetaboLights
MetabolomicsA Clinical Urine Metabolomics Dataset for Urological Malignancies
Renal cell carcinoma, bladder cancer, and prostate cancer rank among the most common urological malignancies, yet clinically satisfactory non-invasive screening tools for these cancers are still lacking. Here we present an untargeted urine metabolomics dataset generated by liquid chromatography coup...
2026-06-27 | MTBLS14865 | MetaboLights
MetabolomicsIntegrated multi-omics of feces, plasm aand urine can describe and differentiate pediatric active Crohn’s Disease from remission

Background

This study aimed to obtain a holistic view of remission in pediatric Crohn’s Disease (CD) by integrating six omics datasets from three anatomical compartments.


Methods

Patients with fecal calprotectin below 250 mg/kg were c...

2025-07-09 | MTBLS9877 | MetaboLights
MetabolomicsTissue, urine and serum NMR metabolomics dataset from a 5/6 nephrectomy rat model of chronic kidney disease

Serum, urine and tissue from a rat model of chronic kidney disease (CKD) were analysed using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics methods, and compared with samples from sham operated rats. Both urine and serum were sampled at multiple timepoints, and the results have ...

2020-11-16 | MTBLS2052 | MetaboLights
MetabolomicsSearching for metabolic changes in urine headspace composition as an effect of strenuous walking
The present investigation uses proton transfer reaction mass spectrometry (PTR-MS) combined with multivariate and univariate statistical analyses to study potential biomarkers for altered metabolism in urine due to strenuous walking. Urine samples, in concurrence with breath and blood samples, were ...
2016-12-14 | MTBLS164 | MetaboLights
MetabolomicsMetabolomics Study of Serum and Urine Samples Reveals Metabolic Pathways and Biomarkers Associated with Pelvic Organ Prolapse
Pelvic organ prolapse (POP) is a common medical condition among women and involves complicated diagnostics and controversial surgical management. The exact molecular mechanism underlying POP is poorly understood, especially at the metabolism level. To explore the metabolic mechanism underlying POP a...
2019-08-14 | MTBLS1033 | MetaboLights
MetabolomicsNMR- and LC–MS/MS-based urine metabolomic investigation of the subacute effects of hexabromocyclododecane in mice (NMR assay)
In the present study, both untargeted and targeted metabolomics approaches were used to evaluate the subacute effects of hexabromocyclododecane (HBCD) on mice urine metabolome. Untargeted metabolomics based on 1H NMR showed that HBCD exposure disturbed mice metabolism in both dosed groups, especiall...
2015-02-14 | MTBLS166 | MetaboLights
MetabolomicsAssessment of automated trimethylsilyl derivatisation protocols for GC-MS-based untargeted metabolomic analysis of urine
GC-MS is a commonly used metabolomic platform for the analysis of urine. A key step in the preparation of samples for GC-MS is derivatisation, in particular, methoximation and trimethylsilylation. This paper presents an assessment of automated derivatisation protocols for GC-MS-based untargeted meta...
2015-09-28 | MTBLS171 | MetaboLights
MetabolomicsCharacterization of trotter horses urine metabolome by means of proton nuclear magnetic resonance spectroscopy
BACKGROUND: Metabolomics has been recognized as a powerful approach for disease screening. In order to highlight potential health issues in subjects, a key factor is the possibility to compare quantitatively the metabolome of their biofluids with reference values from healthy individuals. Such effor...
2019-02-12 | MTBLS675 | MetaboLights
MetabolomicsGut Microbiota and Urine Metabolomics Signature in Autism Spectrum Disorder children from Southern China

To determine the gut microbiota and urine metabolomics signature and identify the regional characteristics in Autism spectrum disorder (ASD), we conducted a cohort study of 88 well-characterized participants from Guangxi Zhuang Autonomous Region in Southern China. Gut microbiota and urine metabo...

2025-06-16 | MTBLS12605 | MetaboLights
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