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TranscriptomicsEffects of ursolic acid and tomatidine on skeletal muscle mRNA expression in aged mice.
For additional details see Ebert et al, Identification and Small Molecule Inhibition of an ATF4-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy. Weight-matched cohorts of 22-month-old male C57BL/6 mice were provided ad libitum access to standard chow (control) or standard chow ...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-72651 | biostudies-arrayexpress
ProteomicsTMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid inhibition of colorectal cancer
Purpose: Ursolic Acid (UA), a triterpenoid extracted from Hedyotis Diffusa Willd. (HDW), is known for its anti-inflammatory, antioxidant, and antitumor effects. Nevertheless, the mechanisms underlying UA's anti-colorectal cancer (CRC) effects remain insufficiently understood. This study is aim to id...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD063684 | Pride
Colorectal cancer  hedyotis diffusa willd  ursolic acid  rplp1  tandem mass tags 
GenomicsUrsolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins
Ursolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins
PRJNA1055032 | ENA
GenomicsUrsolic acid regulates inflammatory cell infiltration to prevent ulcerative colitis
Ursolic acid regulates inflammatory cell infiltration to prevent ulcerative colitis
PRJNA633156 | ENA
TranscriptomicsEffect of ursolic acid on mouse skeletal muscle mRNA levels
The goal of these studies was to determine the effects of ursolic acid on skeletal muscle mRNA levels in wild-type mice
ORGANISM(S): Mus musculus 
2011-06-08 | GSE28017 | GEO
TranscriptomicsUrsolic acid attenuates oligospermia in busulfan-induced mice by promoting motor proteins
This investigation scrutinizes the implications and mechanistic underpinnings of ursolic acid's effect on busulfan-induced oligospermia in mouse models. A single intraperitoneal injection at a dose of 30mg/kg of busulfan induced oligospermia, and two weeks later, the mice were treated with varied do...
ORGANISM(S): Mus musculus 
2024-02-17 | GSE251662 | GEO
GenomicsDietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia [RNA-seq]
Dietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia [RNA-seq]
PRJNA1438730 | ENA
GenomicsUrsolic acid-induced DECR1 degradation via NF-κB/NLRP3 pathway inihibits vascular calcification
Ursolic acid-induced DECR1 degradation via NF-κB/NLRP3 pathway inihibits vascular calcification
PRJNA1159693 | ENA
TranscriptomicsDietary supplementation with ursolic acid preserves skeletal muscle mass and strength in mouse models of cancer cachexia [RNA-seq]
Skeletal muscle atrophy is a devastating and defining feature of cancer cachexia that reduces quality of life, treatment tolerance, and survival, but cannot be prevented or reversed by current management strategies. Ursolic acid is a natural dietary compound that has been shown to inhibit atrophy-as...
ORGANISM(S): Mus musculus 
2026-05-05 | GSE325158 | GEO
TranscriptomicsUrsolic acid-induced DECR1 degradation via NF-κB/NLRP3 pathway inihibits vascular calcification
In this study, we repoort the protective effect of ursolic acid (UA) on vascular calcification in chronic kidney disease. To elucidate the molecular mechanism underlying the anti-vascular calcification effect of UA, we performed RNA-seq to identify the gene expresion under UA treatmment.
ORGANISM(S): Homo sapiens 
2024-09-13 | GSE276910 | GEO
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