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TranscriptomicsTranscription profiling by array of human umbilical vein endothelial cells treated with valproic acid
Valproic acid (VPA) is a short-chain fatty acid used in the treatment of epilepsy and also considered to be an epigenetic modifier by functioning as a histone deacetylase (HDAC)-inhibitor. The aim of this study was to search for gene altered by VPA in human endothelial cells. Human umbilical vein en...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-23909 | biostudies-arrayexpress
TranscriptomicsExpression data of mice cochlea treated with L-methionine and valproic acid.
Treatment of DBA/2J mice with a combination of L-methionine and valproic acid significantly attenuated progressive hearing loss. We examined gene expression in the whole cochlea of the mice. This study was aimed to detect genes of which change in expression levels were associated with attenuation of...
ORGANISM(S): Mus musculus 
2015-04-15 | E-GEOD-62173 | biostudies-arrayexpress
TranscriptomicsValproic acid achieves its anticancer activity by re-expression of cyclin D2
In this study we could show that the treatment of primary murine prostate cancer(PCa) cells derived from the well-established TRAMP (transgenic adenocarcinoma ofmouse prostate) model with the histone deacetylase inhibitor (HDI) valproic acid (VPA) has an anti-proliferative, anti-migrative and anti-i...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-34072 | biostudies-arrayexpress
TranscriptomicsAcute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder
The aim of the study was to investigate the involvement of the mTOR pathway in the autism spectrum disorder. Adolescent male rats, prenatally exposed to valproic acid (500 mg/kg ip on gestational day 12.5), were treated with the mTOR inhibitor rapamycin (10 mg/kg, ip, two consecutive days starting a...
ORGANISM(S): Rattus norvegicus 
2022-09-06 | E-MTAB-12056 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chronic lymphocytic leukemia cells treated with valproic acid
Epigenetic code modifications by histone deacetylase inhibitors (HDACi) have recently been proposed as potential new therapies for hematological malignancies. Chronic Lymphocytic Leukemia (CLL) remains incurable despite the introduction of new treatments. CLL cells are characterized by an apoptosis ...
ORGANISM(S): Homo sapiens 
2009-09-17 | E-GEOD-14973 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of amiodarone, valproic acid, and tetracycline induced steatosis in C57BL/6 mice
Toxicogenomics (tgx) is used as a tool to identify mechanisms and markers of steatosis in C57BL/6 mice treated by oral gavage using amiodarone (AMD), valproic acid (VPA), and tetracycline (TET). Critical doses for tgx analysis were derived from a 25 day dose range finding study. For tgx analysis, l...
ORGANISM(S): Mus musculus 
2014-02-25 | E-GEOD-48126 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse control 25-dpc embryos from control vs. valproic acid (VPA) treated dams and control P19 mouse EC cells vs 1 mM sodium valproate for 24 h
Valproic acid (VPA) is a potent inducer of neural tube defects (NTDs), but its mechanism of teratogenicity is not known. To study the transcriptional response of VPA during the susceptible period, i.e. when VPA is likely to exert most of its teratogenic effect, RNA was extracted from 8.25-dpc embryo...
ORGANISM(S): Mus musculus 
2004-08-01 | E-MEXP-45 | biostudies-arrayexpress
TranscriptomicsExpression data from human hepatic stellate cell line LX2 treated with suberoylanilide hydroxamic acid (SAHA) or valproic acid (VPA)
Suberoylanilide hydroxamic acid (SAHA) and valproic acid (VPA) are both histone deacetylases inhibitor (HDACi), and are able to attenuate the activation of hepatic stelllate cells. To explore the underlying molecular mechanisms, we performed gene expression profile analyses of human hepatic stellate...
ORGANISM(S): Homo sapiens 
2016-04-07 | E-MTAB-3764 | biostudies-arrayexpress
TranscriptomicsNeural embryonic stem cell (ESTn) test dose-responses of Valproic Acid, Cyproconazole and Hexaconazole in the neural embryonic stem cell test.
Effects of Valproic Acid, Cyproconazole and Hexaconazole on stem cell neural development.
ORGANISM(S): Mus musculus 
2012-07-17 | E-TABM-1205 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stem cells in response to valproic acid and valproic acid analogs
Transcriptional profiling of valproic acid and valproic acid analogs in human embryonic stem cells.
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MEXP-2374 | biostudies-arrayexpress
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