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ProteomicsUbiquitination of the actin polymerase VASP
Filopodia are dynamic, actin-rich structures that extend outward from the cell to explore and respond to cues in the local environment. The actin polymerase VASP is a component of the filopodial tip complex, where it regulates actin polymerization and filopodial dynamics. Previously, we showed that ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-17 | PXD041196 | Pride
Actin  ubiquitin  vasp  post-translational modification 
GenomicsTranscriptome analysis of MCF-7 breast cancer cells in which VASP gene was knocked down
Transcriptome analysis of MCF-7 breast cancer cells in which VASP gene was knocked down
PRJNA562507 | ENA
ProteomicsQuantitative proteomic analysis reveals apoE4-dependent phosphorylation of the actin regulating protein VASP
Apolipoprotein (apo) E4 is the major genetic risk factor for Alzheimer’s Disease (AD). While neurons generally produce a minority of the apoE in the central nervous system, neuronal expression of apoE increases dramatically in response to stress and is sufficient to drive pathology. Currently, the m...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-08 | PXD041205 | Pride
Ubiquitylation Ppis Alzheimer's disease Phosphorylation 
GenomicsTranscriptome analysis of MDA-MB-231 breast cancer cells in which VASP gene was knocked down
Transcriptome analysis of MDA-MB-231 breast cancer cells in which VASP gene was knocked down
PRJNA598040 | ENA
TranscriptomicsTranscriptome analysis of MCF-7 breast cancer cells in which VASP gene was knocked down
Previous studies have shown that the main function of VASP is to regulate the cytoskeleton and play an important role in promoting tumor cell metastasis. In this study, we first reveal that VASP is located in the nucleus of breast cancer cells and elucidate a Wnt/β-catenin/VASP positive feedback loo...
ORGANISM(S): Homo sapiens 
2022-12-25 | GSE136406 | GEO
TranscriptomicsTranscriptome analysis of MDA-MB-231 breast cancer cells in which VASP gene was knocked down
Previous studies have shown that the main function of VASP is to regulate the cytoskeleton and play an important role in promoting tumor cell metastasis. In this study, we first reveal that VASP is located in the nucleus of breast cancer cells and elucidate a Wnt/β-catenin/VASP positive feedback loo...
ORGANISM(S): Homo sapiens 
2022-12-25 | GSE142702 | GEO
ProteomicsEVH1 domain interactors of VASP in mature and immature dendritic cells
Mass spectrometry study of interactor binding to the EVH1 domain of VASP in mature and immature dendritic cells. We performed mass spectrometry study using a specially designed inhibitor that recognizes this characterized motif with high affinity and analyzed the digested peptides by LC-MS. For both...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-20 | PXD030882 | Pride
Dendritic cells Cell migration Actin nucleators Actin dynamics 
UnknownMulti-monoubiquitination controls VASP-mediated actin dynamics.
Not available
S-EPMC10370145 | biostudies-literature
UnknownMulti-monoubiquitylation controls VASP-mediated actin dynamics.
Not available
S-EPMC10917064 | biostudies-literature
UnknownEna/VASP proteins capture actin filament barbed ends.
Not available
S-EPMC2442276 | biostudies-literature
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